Bone density among long-term users of medroxyprogesterone acetate as a contraceptive
The bone density (BD) of 72 women using depot-medroxyprogesterone acetate (DMPA) for at least 1 year was compared with that of 64 women who were not users of hormonal contraceptives. The BD of lumbar spine, femoral neck, Ward's triangle, and trochanter was measured by dual energy X-ray absorptiometry (DEXA-LUNAR DPX). Estradiol (E2) concentrations were measured by radioimmunoassay (RIA). The mean age of DMPA users and nonusers was 31.8 and 31.1 years, respectively. Mean E, was 55.7 pg/mL for users and 149.9 pg/mL for controls (p < 0.001). The BD was significantly lower for DMPA users than for controls in all sites (p < 0.01). In addition, young adult T-scores in the lumbar spine were significantly lower among DMPA users than in controls (p < 0.01). Differences were maintained in a subsample of 47 women per group paired by age and body mass index (BMI). Multiple regression analysis showed that older age, lower BMI, and longer amenorrhea were associated with lower BD in the femoral neck, whereas lower BMI and use of DMPA were associated with lower BD in the lumbar spine.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
1998 |
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| Erschienen: |
1998 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:58 |
|---|---|
| Enthalten in: |
Contraception - 58(1998), 6 vom: 20. Dez., Seite 351-5 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Paiva, L C [VerfasserIn] |
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| Anmerkungen: |
Date Completed 18.05.1999 Date Revised 26.08.2019 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM100291082 |
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| 041 | |a eng | ||
| 100 | 1 | |a Paiva, L C |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Bone density among long-term users of medroxyprogesterone acetate as a contraceptive |
| 264 | 1 | |c 1998 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 18.05.1999 | ||
| 500 | |a Date Revised 26.08.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The bone density (BD) of 72 women using depot-medroxyprogesterone acetate (DMPA) for at least 1 year was compared with that of 64 women who were not users of hormonal contraceptives. The BD of lumbar spine, femoral neck, Ward's triangle, and trochanter was measured by dual energy X-ray absorptiometry (DEXA-LUNAR DPX). Estradiol (E2) concentrations were measured by radioimmunoassay (RIA). The mean age of DMPA users and nonusers was 31.8 and 31.1 years, respectively. Mean E, was 55.7 pg/mL for users and 149.9 pg/mL for controls (p < 0.001). The BD was significantly lower for DMPA users than for controls in all sites (p < 0.01). In addition, young adult T-scores in the lumbar spine were significantly lower among DMPA users than in controls (p < 0.01). Differences were maintained in a subsample of 47 women per group paired by age and body mass index (BMI). Multiple regression analysis showed that older age, lower BMI, and longer amenorrhea were associated with lower BD in the femoral neck, whereas lower BMI and use of DMPA were associated with lower BD in the lumbar spine | ||
| 650 | 4 | |a Clinical Trial | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Americas | |
| 650 | 4 | |a Biology | |
| 650 | 4 | |a Brazil | |
| 650 | 4 | |a Comparative Studies | |
| 650 | 4 | |a Contraception | |
| 650 | 4 | |a Contraceptive Agents, Female--pharmacodynamics | |
| 650 | 4 | |a Contraceptive Agents, Progestin--pharmacodynamics | |
| 650 | 4 | |a Contraceptive Agents--pharmacodynamics | |
| 650 | 4 | |a Contraceptive Methods--side effects | |
| 650 | 4 | |a Demographic Factors | |
| 650 | 4 | |a Depo-provera--pharmacodynamics | |
| 650 | 4 | |a Developing Countries | |
| 650 | 4 | |a Family Planning | |
| 650 | 4 | |a Injectables--side effects | |
| 650 | 4 | |a Latin America | |
| 650 | 4 | |a Longterm Effects--women | |
| 650 | 4 | |a Medroxyprogesterone Acetate--pharmacodynamics | |
| 650 | 4 | |a Physiology | |
| 650 | 4 | |a Population | |
| 650 | 4 | |a Population Dynamics | |
| 650 | 4 | |a Research Methodology | |
| 650 | 4 | |a Research Report | |
| 650 | 4 | |a Risk Factors--women | |
| 650 | 4 | |a Skeletal Effects--women | |
| 650 | 4 | |a South America | |
| 650 | 4 | |a Studies | |
| 650 | 4 | |a Time Factors | |
| 650 | 4 | |a Women | |
| 650 | 7 | |a Contraceptive Agents, Female |2 NLM | |
| 650 | 7 | |a Progesterone Congeners |2 NLM | |
| 650 | 7 | |a Estradiol |2 NLM | |
| 650 | 7 | |a 4TI98Z838E |2 NLM | |
| 650 | 7 | |a Medroxyprogesterone Acetate |2 NLM | |
| 650 | 7 | |a C2QI4IOI2G |2 NLM | |
| 700 | 1 | |a Pinto-Neto, A M |e verfasserin |4 aut | |
| 700 | 1 | |a Faundes, A |e verfasserin |4 aut | |
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| 773 | 1 | 8 | |g volume:58 |g year:1998 |g number:6 |g day:20 |g month:12 |g pages:351-5 |
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