Effects of centrally of peripherally injected adrenomedullin on reserpine-induced gastric lesions
Adrenomedullin intracerebroventricularly administered (0.1 to 20 ng/rat i.c.v.), showed significant gastroprotective activity in a dose-dependent manner. When the peptide was intravenously administered (1 to 1000 ng/kg i.v.) it did not show significant gastroprotective activity in the same test. The gastroprotective effect of the peptide (10 ng/rat) was abolished by bilateral adrenalectomy, by pretreatment with the beta-adrenoceptor antagonist, propranolol (1 mg/kg i.p.), or by a calcitonin gene-related peptide (CGRP) receptor antagonist, CGRP-(8-37) fragment (1 or 10 ng/rat i.c.v.). This study showed that adrenomedullin is protective against reserpine-induced gastric lesions, that the action involves sympathetic nerve activity, and moreover interferes with CGRP receptors.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
1998 |
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| Erschienen: |
1998 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:360 |
|---|---|
| Enthalten in: |
European journal of pharmacology - 360(1998), 1 vom: 30. Okt., Seite 51-4 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Clementi, G [VerfasserIn] |
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| Anmerkungen: |
Date Completed 09.02.1999 Date Revised 24.06.2019 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM097820512 |
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| 100 | 1 | |a Clementi, G |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Effects of centrally of peripherally injected adrenomedullin on reserpine-induced gastric lesions |
| 264 | 1 | |c 1998 | |
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| 500 | |a Date Completed 09.02.1999 | ||
| 500 | |a Date Revised 24.06.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Adrenomedullin intracerebroventricularly administered (0.1 to 20 ng/rat i.c.v.), showed significant gastroprotective activity in a dose-dependent manner. When the peptide was intravenously administered (1 to 1000 ng/kg i.v.) it did not show significant gastroprotective activity in the same test. The gastroprotective effect of the peptide (10 ng/rat) was abolished by bilateral adrenalectomy, by pretreatment with the beta-adrenoceptor antagonist, propranolol (1 mg/kg i.p.), or by a calcitonin gene-related peptide (CGRP) receptor antagonist, CGRP-(8-37) fragment (1 or 10 ng/rat i.c.v.). This study showed that adrenomedullin is protective against reserpine-induced gastric lesions, that the action involves sympathetic nerve activity, and moreover interferes with CGRP receptors | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Anti-Ulcer Agents |2 NLM | |
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| 650 | 7 | |a Peptide Fragments |2 NLM | |
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| 650 | 7 | |a Adrenomedullin |2 NLM | |
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| 700 | 1 | |a de Bernardis, E |e verfasserin |4 aut | |
| 700 | 1 | |a Prato, A |e verfasserin |4 aut | |
| 700 | 1 | |a Mangano, N G |e verfasserin |4 aut | |
| 700 | 1 | |a Amico-Roxas, M |e verfasserin |4 aut | |
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