Oxygen free radical on interleukin-1 activity of hemorrhage/resuscitation rat
OBJECTIVE: To investigate the effects of oxygen free radical on the enhancement of IL-1 activity in vivo and in vitro on hemorrhagic and resuscitated rat.
METHODS: 30% of rats total blood volume was withdraw by carotid artery catheter and resuscitated with 2 times of lost blood volume 1 h later.
RESULTS: Plasm IL-1 activity and MDA content increased and SOD activity decreased significantly 1-4 hours after resuscitation. There was a marked correlation between IL-1 activity and MDA content as well as SOD activity. Treatment with SOD as resuscitation prevented the postresuscitation increase in plasma IL-1 activity significantly. Hemorrhage and resuscitation also caused significant decrease of SOD activity and elevation of MDA in peritoneal macrophage 2 hours after resuscitation. After preincubation with SOD for 1 hour, the macrophage presented a much lowered capacity to release IL-1.
CONCLUSION: Oxygen free radical may be one of the most important factors that contribute to elevation of IL-1 level after hemorrhage and resucitation.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
1997 |
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| Erschienen: |
1997 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:77 |
|---|---|
| Enthalten in: |
Zhonghua yi xue za zhi - 77(1997), 8 vom: 06. Aug., Seite 601-3 |
| Sprache: |
Chinesisch |
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| Beteiligte Personen: |
Shi, H [VerfasserIn] |
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| Themen: |
4Y8F71G49Q |
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| Anmerkungen: |
Date Completed 06.11.1998 Date Revised 21.11.2013 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM097108707 |
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| 100 | 1 | |a Shi, H |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Oxygen free radical on interleukin-1 activity of hemorrhage/resuscitation rat |
| 264 | 1 | |c 1997 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 06.11.1998 | ||
| 500 | |a Date Revised 21.11.2013 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: To investigate the effects of oxygen free radical on the enhancement of IL-1 activity in vivo and in vitro on hemorrhagic and resuscitated rat | ||
| 520 | |a METHODS: 30% of rats total blood volume was withdraw by carotid artery catheter and resuscitated with 2 times of lost blood volume 1 h later | ||
| 520 | |a RESULTS: Plasm IL-1 activity and MDA content increased and SOD activity decreased significantly 1-4 hours after resuscitation. There was a marked correlation between IL-1 activity and MDA content as well as SOD activity. Treatment with SOD as resuscitation prevented the postresuscitation increase in plasma IL-1 activity significantly. Hemorrhage and resuscitation also caused significant decrease of SOD activity and elevation of MDA in peritoneal macrophage 2 hours after resuscitation. After preincubation with SOD for 1 hour, the macrophage presented a much lowered capacity to release IL-1 | ||
| 520 | |a CONCLUSION: Oxygen free radical may be one of the most important factors that contribute to elevation of IL-1 level after hemorrhage and resucitation | ||
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Free Radicals |2 NLM | |
| 650 | 7 | |a Interleukin-1 |2 NLM | |
| 650 | 7 | |a Malondialdehyde |2 NLM | |
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| 700 | 1 | |a Qi, D |e verfasserin |4 aut | |
| 700 | 1 | |a Gao, H |e verfasserin |4 aut | |
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