Antioxidant properties of nicergoline; inhibition of brain auto-oxidation and superoxide production of neutrophils in rats
Oxidative stress has been suggested to adversely influence cerebrovascular disorders and some neurodegenerative disorders. We examined whether nicergoline, an agent widely used for treating cerebrovascular disorders and senile mental impairment, possesses antioxidant activities and some beneficial effect on neutrophils generating free radicals. Although nicergoline did not scavenge superoxide produced from a superoxide-generating system, it significantly inhibited superoxide secretion from stimulated neutrophils. Auto-oxidation of brain homogenate of rats, monitored by formation of thiobarbituric acid-reactive substances, was suppressed by nicergoline in a dose-dependent manner. The oxidation of the homogenate was accelerated by activated neutrophils and was significantly suppressed by nicergoline. These observations suggest that nicergoine is an antioxidant that inhibits not only lipid peroxidation but also free radical generation from neutrophils. These properties of nicergoline should be beneficial in some pathological conditions including cerebrovascular and neurodegenerative disorders in which oxidative stress may have a pathoetiological role.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
1998 |
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| Erschienen: |
1998 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:248 |
|---|---|
| Enthalten in: |
Neuroscience letters - 248(1998), 1 vom: 22. Mai, Seite 68-72 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tanaka, M [VerfasserIn] |
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| Themen: |
11062-77-4 |
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| Anmerkungen: |
Date Completed 30.03.1999 Date Revised 01.07.2019 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM096054255 |
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| 100 | 1 | |a Tanaka, M |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Antioxidant properties of nicergoline; inhibition of brain auto-oxidation and superoxide production of neutrophils in rats |
| 264 | 1 | |c 1998 | |
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| 500 | |a Date Completed 30.03.1999 | ||
| 500 | |a Date Revised 01.07.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Oxidative stress has been suggested to adversely influence cerebrovascular disorders and some neurodegenerative disorders. We examined whether nicergoline, an agent widely used for treating cerebrovascular disorders and senile mental impairment, possesses antioxidant activities and some beneficial effect on neutrophils generating free radicals. Although nicergoline did not scavenge superoxide produced from a superoxide-generating system, it significantly inhibited superoxide secretion from stimulated neutrophils. Auto-oxidation of brain homogenate of rats, monitored by formation of thiobarbituric acid-reactive substances, was suppressed by nicergoline in a dose-dependent manner. The oxidation of the homogenate was accelerated by activated neutrophils and was significantly suppressed by nicergoline. These observations suggest that nicergoine is an antioxidant that inhibits not only lipid peroxidation but also free radical generation from neutrophils. These properties of nicergoline should be beneficial in some pathological conditions including cerebrovascular and neurodegenerative disorders in which oxidative stress may have a pathoetiological role | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Antioxidants |2 NLM | |
| 650 | 7 | |a Superoxides |2 NLM | |
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| 700 | 1 | |a Okamoto, K |e verfasserin |4 aut | |
| 700 | 1 | |a Hirai, S |e verfasserin |4 aut | |
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