Variations in the NRAMP1 gene and susceptibility to tuberculosis in West Africans
BACKGROUND: Genetic factors may affect the susceptibility to tuberculosis, but no specific genes governing susceptibility have been identified. In mice, natural resistance to infection with some mycobacteria is influenced by the gene for natural-resistance-associated macrophage protein 1 (Nramp1), but the role of the human homologue of this gene, NRAMP1, in tuberculosis is unknown. We typed polymorphisms in NRAMP1 in a case-control study of tuberculosis in the Gambia, West Africa.
METHODS: Sequence-specific oligonucleotide hybridization and microsatellite analysis were used to type NRAMP1 polymorphisms in 410 adults (mean age, 34.7 years) with smear-positive pulmonary tuberculosis and 417 ethnically matched, healthy controls. Patients with human immunodeficiency virus infection were excluded.
RESULTS: Four NRAMP1 polymorphisms were each significantly associated with tuberculosis. Subjects who were heterozygous for two NRAMP1 polymorphisms in intron 4 and the 3' untranslated region of the gene were particularly overrepresented among those with tuberculosis, as compared with those with the most common NRAMP1 genotype (odds ratio, 4.07; 95 percent confidence interval, 1.86 to 9.12; chi-square= 14.58; P<0.001).
CONCLUSIONS: Genetic variation in NRAMP1 affects susceptibility to tuberculosis in West Africans.
| Errataetall: |
CommentIn: N Engl J Med. 1998 Mar 5;338(10):677-8. - PMID 9486998 |
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| Medienart: |
Artikel |
| Erscheinungsjahr: |
1998 |
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| Erschienen: |
1998 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:338 |
|---|---|
| Enthalten in: |
The New England journal of medicine - 338(1998), 10 vom: 05. März, Seite 640-4 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Bellamy, R [VerfasserIn] |
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| Anmerkungen: |
Date Completed 05.03.1998 Date Revised 08.04.2022 published: Print CommentIn: N Engl J Med. 1998 Mar 5;338(10):677-8. - PMID 9486998 Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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NLM094291020 |
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| 100 | 1 | |a Bellamy, R |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Variations in the NRAMP1 gene and susceptibility to tuberculosis in West Africans |
| 264 | 1 | |c 1998 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a Date Completed 05.03.1998 | ||
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| 500 | |a published: Print | ||
| 500 | |a CommentIn: N Engl J Med. 1998 Mar 5;338(10):677-8. - PMID 9486998 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Genetic factors may affect the susceptibility to tuberculosis, but no specific genes governing susceptibility have been identified. In mice, natural resistance to infection with some mycobacteria is influenced by the gene for natural-resistance-associated macrophage protein 1 (Nramp1), but the role of the human homologue of this gene, NRAMP1, in tuberculosis is unknown. We typed polymorphisms in NRAMP1 in a case-control study of tuberculosis in the Gambia, West Africa | ||
| 520 | |a METHODS: Sequence-specific oligonucleotide hybridization and microsatellite analysis were used to type NRAMP1 polymorphisms in 410 adults (mean age, 34.7 years) with smear-positive pulmonary tuberculosis and 417 ethnically matched, healthy controls. Patients with human immunodeficiency virus infection were excluded | ||
| 520 | |a RESULTS: Four NRAMP1 polymorphisms were each significantly associated with tuberculosis. Subjects who were heterozygous for two NRAMP1 polymorphisms in intron 4 and the 3' untranslated region of the gene were particularly overrepresented among those with tuberculosis, as compared with those with the most common NRAMP1 genotype (odds ratio, 4.07; 95 percent confidence interval, 1.86 to 9.12; chi-square= 14.58; P<0.001) | ||
| 520 | |a CONCLUSIONS: Genetic variation in NRAMP1 affects susceptibility to tuberculosis in West Africans | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Adult | |
| 650 | 4 | |a Africa | |
| 650 | 4 | |a Africa South Of The Sahara | |
| 650 | 4 | |a Age Factors | |
| 650 | 4 | |a Biology | |
| 650 | 4 | |a Demographic Factors | |
| 650 | 4 | |a Developing Countries | |
| 650 | 4 | |a Diseases | |
| 650 | 4 | |a English Speaking Africa | |
| 650 | 4 | |a Gambia | |
| 650 | 4 | |a Genetics | |
| 650 | 4 | |a Infections | |
| 650 | 4 | |a Population | |
| 650 | 4 | |a Population Characteristics | |
| 650 | 4 | |a Research Report | |
| 650 | 4 | |a Risk Factors | |
| 650 | 4 | |a Tuberculosis | |
| 650 | 4 | |a Western Africa | |
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| 700 | 1 | |a Whittle, H C |e verfasserin |4 aut | |
| 700 | 1 | |a Hill, A V |e verfasserin |4 aut | |
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