Effects of ovariectomy and estrogen replacement on aorta angiotensin-converting enzyme activity in rats
We investigated the possibility that physiological doses of estrogen protect against atherosclerotic change produced by changes in vascular angiotensin-converting enzyme (ACE) activity. Rats were ovariectomized, and after 14 days, treated with estradiol-17 beta (0.2 microgram/rat) for 14 weeks. Aorta ACE activity significantly increased in the ovariectomized rats, and decreased following estradiol-17 beta administration to a level not different from proestrous control rats. These results suggest that the lack of estrogenic action increases atherosclerotic change associated with changes in aorta ACE activity and that estrogen replacement therapy reduces the risk of atherosclerotic change associated with the decrease of aorta ACE activity.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
1997 |
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| Erschienen: |
1997 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:73 |
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| Enthalten in: |
Japanese journal of pharmacology - 73(1997), 4 vom: 15. Apr., Seite 361-3 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tanaka, M [VerfasserIn] |
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| Themen: |
4TI98Z838E |
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| Anmerkungen: |
Date Completed 27.08.1997 Date Revised 25.07.2019 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM091208688 |
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| 100 | 1 | |a Tanaka, M |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Effects of ovariectomy and estrogen replacement on aorta angiotensin-converting enzyme activity in rats |
| 264 | 1 | |c 1997 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a Date Completed 27.08.1997 | ||
| 500 | |a Date Revised 25.07.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a We investigated the possibility that physiological doses of estrogen protect against atherosclerotic change produced by changes in vascular angiotensin-converting enzyme (ACE) activity. Rats were ovariectomized, and after 14 days, treated with estradiol-17 beta (0.2 microgram/rat) for 14 weeks. Aorta ACE activity significantly increased in the ovariectomized rats, and decreased following estradiol-17 beta administration to a level not different from proestrous control rats. These results suggest that the lack of estrogenic action increases atherosclerotic change associated with changes in aorta ACE activity and that estrogen replacement therapy reduces the risk of atherosclerotic change associated with the decrease of aorta ACE activity | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Nakaya, S |e verfasserin |4 aut | |
| 700 | 1 | |a Watanabe, M |e verfasserin |4 aut | |
| 700 | 1 | |a Kumai, T |e verfasserin |4 aut | |
| 700 | 1 | |a Tateishi, T |e verfasserin |4 aut | |
| 700 | 1 | |a Kobayashi, S |e verfasserin |4 aut | |
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