Effects of androgen receptor polyglutamine tract expansion on proliferation of NG108-15 cells
Expansion of the polyglutamine tracts in the androgen receptor (AR) has been recognized as a cause of X-linked spinal and bulbar muscular atrophy (SBMA). In the present study, NG108-15 cells were stably transfected with expression vectors coding for either the wild type (WT) AR gene (CAG repeat number = 22) or a mutated (MT) AR gene (CAG repeat number = 52). Cells proliferation and cell cycle parameters were evaluated for NG108-15-WT and NG108-15-MT cells in the presence or absence of androgen. NG108-15-WT cells demonstrated an androgen-dependent increase in cell number, while NG108-15-MT cells did not. Our results demonstrate that expansion of polyglutamine tracts in the AR may affect the proliferation and differentiation of nerve cells.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
1997 |
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| Erschienen: |
1997 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:222 |
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| Enthalten in: |
Neuroscience letters - 222(1997), 2 vom: 31. Jan., Seite 83-6 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Nakajima, H [VerfasserIn] |
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| Themen: |
26700-71-0 |
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| Anmerkungen: |
Date Completed 12.05.1997 Date Revised 01.07.2019 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM090677668 |
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| 041 | |a eng | ||
| 100 | 1 | |a Nakajima, H |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Effects of androgen receptor polyglutamine tract expansion on proliferation of NG108-15 cells |
| 264 | 1 | |c 1997 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 12.05.1997 | ||
| 500 | |a Date Revised 01.07.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Expansion of the polyglutamine tracts in the androgen receptor (AR) has been recognized as a cause of X-linked spinal and bulbar muscular atrophy (SBMA). In the present study, NG108-15 cells were stably transfected with expression vectors coding for either the wild type (WT) AR gene (CAG repeat number = 22) or a mutated (MT) AR gene (CAG repeat number = 52). Cells proliferation and cell cycle parameters were evaluated for NG108-15-WT and NG108-15-MT cells in the presence or absence of androgen. NG108-15-WT cells demonstrated an androgen-dependent increase in cell number, while NG108-15-MT cells did not. Our results demonstrate that expansion of polyglutamine tracts in the AR may affect the proliferation and differentiation of nerve cells | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Androgens |2 NLM | |
| 650 | 7 | |a Peptides |2 NLM | |
| 650 | 7 | |a Receptors, Androgen |2 NLM | |
| 650 | 7 | |a polyglutamine |2 NLM | |
| 650 | 7 | |a 26700-71-0 |2 NLM | |
| 700 | 1 | |a Kimura, F |e verfasserin |4 aut | |
| 700 | 1 | |a Nakagawa, T |e verfasserin |4 aut | |
| 700 | 1 | |a Ikemoto, T |e verfasserin |4 aut | |
| 700 | 1 | |a Furutama, D |e verfasserin |4 aut | |
| 700 | 1 | |a Shinoda, K |e verfasserin |4 aut | |
| 700 | 1 | |a Kato, S |e verfasserin |4 aut | |
| 700 | 1 | |a Shimizu, A |e verfasserin |4 aut | |
| 700 | 1 | |a Ohsawa, N |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Neuroscience letters |d 1975 |g 222(1997), 2 vom: 31. Jan., Seite 83-6 |w (DE-627)NLM000386529 |x 1872-7972 |7 nnns |
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