Serum oncostatin M in multiple myeloma : association with prognostic factors
The serum concentration of oncostatin M (OSM) was measured in 40 multiple myeloma patients at diagnosis. Serum OSM level exceeded the sensitivity limit of the ELISA assay in eight (20%) of these patients (OSM+ patients). The serum levels of IL-6, another member of the gp180 cytokine family and C-reactive protein (CRP) as a surrogate of IL-6 were significantly higher in OSM+ patients. There was a trend towards higher serum beta 2M concentration in OSM+ patients, whereas there was no difference in the serum sIL-6R level or clinical data (age, gender, myeloma protein or stage) between the two groups. Two human myeloma cell lines secreted OSM and IL-6, but not IL-11 or leukaemia inhibitory factor (LIF), which suggests an important role for OSM and IL-6 in supporting growth of myeloma cells.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
1997 |
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| Erschienen: |
1997 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:96 |
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| Enthalten in: |
British journal of haematology - 96(1997), 1 vom: 21. Jan., Seite 158-60 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Koskela, K [VerfasserIn] |
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| Themen: |
106956-32-5 |
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| Anmerkungen: |
Date Completed 19.02.1997 Date Revised 05.07.2019 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM089780817 |
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| 100 | 1 | |a Koskela, K |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Serum oncostatin M in multiple myeloma |b association with prognostic factors |
| 264 | 1 | |c 1997 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 19.02.1997 | ||
| 500 | |a Date Revised 05.07.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The serum concentration of oncostatin M (OSM) was measured in 40 multiple myeloma patients at diagnosis. Serum OSM level exceeded the sensitivity limit of the ELISA assay in eight (20%) of these patients (OSM+ patients). The serum levels of IL-6, another member of the gp180 cytokine family and C-reactive protein (CRP) as a surrogate of IL-6 were significantly higher in OSM+ patients. There was a trend towards higher serum beta 2M concentration in OSM+ patients, whereas there was no difference in the serum sIL-6R level or clinical data (age, gender, myeloma protein or stage) between the two groups. Two human myeloma cell lines secreted OSM and IL-6, but not IL-11 or leukaemia inhibitory factor (LIF), which suggests an important role for OSM and IL-6 in supporting growth of myeloma cells | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Interleukin-6 |2 NLM | |
| 650 | 7 | |a OSM protein, human |2 NLM | |
| 650 | 7 | |a Peptides |2 NLM | |
| 650 | 7 | |a beta 2-Microglobulin |2 NLM | |
| 650 | 7 | |a Oncostatin M |2 NLM | |
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| 700 | 1 | |a Pelliniemi, T T |e verfasserin |4 aut | |
| 700 | 1 | |a Remes, K |e verfasserin |4 aut | |
| 700 | 1 | |a Rajamäki, A |e verfasserin |4 aut | |
| 700 | 1 | |a Pulkki, K |e verfasserin |4 aut | |
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