Composite biomaterials based on ceramic polymers. I. Reinforced systems based on Al2O3/PMMA/PLLA
Composite biomaterials with good mechanical response and a partially biodegradable character were prepared by the free radical polymerization of mixtures of alpha-Al2O3, low-molecular-weight but crystalline poly(L-lactic acid) (PLLA), and methyl methacrylate (MMA). Cylindrical specimens prepared with different composition were characterized by thermogravimetry, calorimetry, 1H-NMR spectroscopy, and x-ray diffraction (XRD). The in vitro biodegradative process was studied in different media, following variations of the pH, gravimetric weight loss of the specimens, and crystalline domain change by XRD after immersion in pure water and buffered solutions at pH 4.0 and pH 8.0 for 90 days. Formation of a relatively porous structure with good cohesion after the biodegradative treatment (confirmed by SEM) was observed. These systems can be considered for applications in orthopedic surgery as filling biomaterials and even as control drug-delivery systems.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
1996 |
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| Erschienen: |
1996 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:30 |
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| Enthalten in: |
Journal of biomedical materials research - 30(1996), 4 vom: 01. Apr., Seite 515-22 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Rodríguez-Lorenzo, L M [VerfasserIn] |
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| Anmerkungen: |
Date Completed 23.10.1996 Date Revised 09.04.2022 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM088162761 |
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| 100 | 1 | |a Rodríguez-Lorenzo, L M |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Composite biomaterials based on ceramic polymers. I. Reinforced systems based on Al2O3/PMMA/PLLA |
| 264 | 1 | |c 1996 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 23.10.1996 | ||
| 500 | |a Date Revised 09.04.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Composite biomaterials with good mechanical response and a partially biodegradable character were prepared by the free radical polymerization of mixtures of alpha-Al2O3, low-molecular-weight but crystalline poly(L-lactic acid) (PLLA), and methyl methacrylate (MMA). Cylindrical specimens prepared with different composition were characterized by thermogravimetry, calorimetry, 1H-NMR spectroscopy, and x-ray diffraction (XRD). The in vitro biodegradative process was studied in different media, following variations of the pH, gravimetric weight loss of the specimens, and crystalline domain change by XRD after immersion in pure water and buffered solutions at pH 4.0 and pH 8.0 for 90 days. Formation of a relatively porous structure with good cohesion after the biodegradative treatment (confirmed by SEM) was observed. These systems can be considered for applications in orthopedic surgery as filling biomaterials and even as control drug-delivery systems | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Biocompatible Materials |2 NLM | |
| 650 | 7 | |a Indicators and Reagents |2 NLM | |
| 650 | 7 | |a Lactates |2 NLM | |
| 650 | 7 | |a Methylmethacrylates |2 NLM | |
| 650 | 7 | |a Polyesters |2 NLM | |
| 650 | 7 | |a Polymers |2 NLM | |
| 650 | 7 | |a Lactic Acid |2 NLM | |
| 650 | 7 | |a 33X04XA5AT |2 NLM | |
| 650 | 7 | |a poly(lactide) |2 NLM | |
| 650 | 7 | |a 459TN2L5F5 |2 NLM | |
| 650 | 7 | |a Aluminum Oxide |2 NLM | |
| 650 | 7 | |a LMI26O6933 |2 NLM | |
| 700 | 1 | |a Salinas, A J |e verfasserin |4 aut | |
| 700 | 1 | |a Vallet-Regí, M |e verfasserin |4 aut | |
| 700 | 1 | |a San Román, J |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of biomedical materials research |d 1967 |g 30(1996), 4 vom: 01. Apr., Seite 515-22 |w (DE-627)NLM000041386 |x 0021-9304 |7 nnns |
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