The effects of prefrontal intracortical microinjections of an alpha-2 agonist, alpha-2 antagonist and lidocaine on the delayed alternation performance of aged rats
A selective alpha-2 agonist medetomidine, a selective alpha-2 antagonist atipamezole and lidocaine were injected into the prefrontal cortex of aged rats that had been trained to perform a delayed alternation (DA) task in a T maze. Medetomidine at the dose of 0.01 microgram/microliter improved the memory task performance in four of five rats. The fifth rat improved its performance at the dose of 1.0 microgram/microliter. Atipamezole did not have any effect on the task performance. The effect of a systemic dose of medetomidine (3 micrograms/kg), which was previously shown to improve the task performance in old rats, was reversed by an intracortical injection of atipamezole. Lidocaine impaired the DA performance significantly. The results suggest that the beneficial effects of medetomidine on the working memory of old rats are mediated at least partly through the prefrontal cortex.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
1996 |
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| Erschienen: |
1996 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:40 |
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| Enthalten in: |
Brain research bulletin - 40(1996), 2 vom: 26., Seite 117-9 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tanila, H [VerfasserIn] |
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| Themen: |
03N9U5JAF6 |
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| Anmerkungen: |
Date Completed 23.10.1996 Date Revised 19.07.2019 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM086964348 |
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| 041 | |a eng | ||
| 100 | 1 | |a Tanila, H |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The effects of prefrontal intracortical microinjections of an alpha-2 agonist, alpha-2 antagonist and lidocaine on the delayed alternation performance of aged rats |
| 264 | 1 | |c 1996 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 23.10.1996 | ||
| 500 | |a Date Revised 19.07.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a A selective alpha-2 agonist medetomidine, a selective alpha-2 antagonist atipamezole and lidocaine were injected into the prefrontal cortex of aged rats that had been trained to perform a delayed alternation (DA) task in a T maze. Medetomidine at the dose of 0.01 microgram/microliter improved the memory task performance in four of five rats. The fifth rat improved its performance at the dose of 1.0 microgram/microliter. Atipamezole did not have any effect on the task performance. The effect of a systemic dose of medetomidine (3 micrograms/kg), which was previously shown to improve the task performance in old rats, was reversed by an intracortical injection of atipamezole. Lidocaine impaired the DA performance significantly. The results suggest that the beneficial effects of medetomidine on the working memory of old rats are mediated at least partly through the prefrontal cortex | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Adrenergic alpha-Agonists |2 NLM | |
| 650 | 7 | |a Adrenergic alpha-Antagonists |2 NLM | |
| 650 | 7 | |a Imidazoles |2 NLM | |
| 650 | 7 | |a atipamezole |2 NLM | |
| 650 | 7 | |a 03N9U5JAF6 |2 NLM | |
| 650 | 7 | |a Lidocaine |2 NLM | |
| 650 | 7 | |a 98PI200987 |2 NLM | |
| 650 | 7 | |a Medetomidine |2 NLM | |
| 650 | 7 | |a MR15E85MQM |2 NLM | |
| 700 | 1 | |a Rämä, P |e verfasserin |4 aut | |
| 700 | 1 | |a Carlson, S |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Brain research bulletin |d 1986 |g 40(1996), 2 vom: 26., Seite 117-9 |w (DE-627)NLM000391913 |x 1873-2747 |7 nnns |
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