Scintigraphic characterization of expansive lesions located in the adrenals. Comparison with magnetic resonance imaging
In this study, 35 patients (11 men and 24 women, mean age 47 +/- 16 years) with unilateral adrenal masses underwent nor-cholesterol (nor-Chol) (n = 11), metaiodobenzylguanidine (MIBG) (n = 15) or nor-Chol and MIBG (n = 9) radionuclide studies. In all patients Magnetic Resonance (MR) adrenal imaging was also performed. In 19 (54%) patients, no laboratory abnormalities of adrenal function were observed. In the other 16 (46%) patients, adrenal hyperfunction was found. In 21 lesions, histology showed 10 pheochromocytomas (Pheos), 6 adenomas, 3 metastases, 1 cyst and 1 nodular focal liver hyperplasia. In the remaining 14 lesions, increased cortisol (n = 4) or aldosterone (n = 2) levels and/or intense nor-Chol uptake (n = 14) were considered suggestive of adenoma. Diagnostic accuracy of both nor-Chol and MIBG radionuclide studies in correctly identifying adenoma or Pheos was 100%. Conversely, qualitative MR signal intensity (SI) analysis on T2-weighted images did not allow to accurately distinguish lesions of different nature. In particular, 10 Pheos, 8 adenomas, 3 mestastasis and 1 cyst clearly showed on T2-weighted images higher SI than the liver; 5 adenomas had a slight higher SI; the remaining lesions (7 adenomas and 1 liver hyperplasia) exhibited low SI. In conclusion, adrenal scintigraphy using nor-Chol or MIBG allows to identify adenomas and Pheos, respectively. Conversely, qualitative MR SI analysis cannot differentiate different adrenal lesion (Pheos, adenoma, metastasis and cyst) and yields heterogeneous results in adenomas.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
1995 |
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| Erschienen: |
1995 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:90 |
|---|---|
| Enthalten in: |
La Radiologia medica - 90(1995), 6 vom: 16. Dez., Seite 756-65 |
| Sprache: |
Italienisch |
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| Weiterer Titel: |
Caratterizzazione scintigrafica delle lesioni espansive a sede surrenalica. Confronto con l'imaging a Risonanza Magnetica |
|---|
| Beteiligte Personen: |
Maurea, S [VerfasserIn] |
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| Themen: |
3-Iodobenzylguanidine |
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| Anmerkungen: |
Date Completed 20.08.1996 Date Revised 23.11.2016 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM086583204 |
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| 100 | 1 | |a Maurea, S |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Scintigraphic characterization of expansive lesions located in the adrenals. Comparison with magnetic resonance imaging |
| 246 | 3 | 3 | |a Caratterizzazione scintigrafica delle lesioni espansive a sede surrenalica. Confronto con l'imaging a Risonanza Magnetica |
| 264 | 1 | |c 1995 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a Date Completed 20.08.1996 | ||
| 500 | |a Date Revised 23.11.2016 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a In this study, 35 patients (11 men and 24 women, mean age 47 +/- 16 years) with unilateral adrenal masses underwent nor-cholesterol (nor-Chol) (n = 11), metaiodobenzylguanidine (MIBG) (n = 15) or nor-Chol and MIBG (n = 9) radionuclide studies. In all patients Magnetic Resonance (MR) adrenal imaging was also performed. In 19 (54%) patients, no laboratory abnormalities of adrenal function were observed. In the other 16 (46%) patients, adrenal hyperfunction was found. In 21 lesions, histology showed 10 pheochromocytomas (Pheos), 6 adenomas, 3 metastases, 1 cyst and 1 nodular focal liver hyperplasia. In the remaining 14 lesions, increased cortisol (n = 4) or aldosterone (n = 2) levels and/or intense nor-Chol uptake (n = 14) were considered suggestive of adenoma. Diagnostic accuracy of both nor-Chol and MIBG radionuclide studies in correctly identifying adenoma or Pheos was 100%. Conversely, qualitative MR signal intensity (SI) analysis on T2-weighted images did not allow to accurately distinguish lesions of different nature. In particular, 10 Pheos, 8 adenomas, 3 mestastasis and 1 cyst clearly showed on T2-weighted images higher SI than the liver; 5 adenomas had a slight higher SI; the remaining lesions (7 adenomas and 1 liver hyperplasia) exhibited low SI. In conclusion, adrenal scintigraphy using nor-Chol or MIBG allows to identify adenomas and Pheos, respectively. Conversely, qualitative MR SI analysis cannot differentiate different adrenal lesion (Pheos, adenoma, metastasis and cyst) and yields heterogeneous results in adenomas | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Contrast Media |2 NLM | |
| 650 | 7 | |a Iodine Radioisotopes |2 NLM | |
| 650 | 7 | |a Iodobenzenes |2 NLM | |
| 650 | 7 | |a Selenium Radioisotopes |2 NLM | |
| 650 | 7 | |a 3-Iodobenzylguanidine |2 NLM | |
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| 650 | 7 | |a Cholesterol |2 NLM | |
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| 700 | 1 | |a Lastoria, S |e verfasserin |4 aut | |
| 700 | 1 | |a Caracò, C |e verfasserin |4 aut | |
| 700 | 1 | |a Castelli, L |e verfasserin |4 aut | |
| 700 | 1 | |a Varrella, P |e verfasserin |4 aut | |
| 700 | 1 | |a Filice, S |e verfasserin |4 aut | |
| 700 | 1 | |a Rossi, R |e verfasserin |4 aut | |
| 700 | 1 | |a Salvatore, M |e verfasserin |4 aut | |
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