Choice of agent for peripheral thrombolysis
Evidence has been accumulating that tissue plasminogen activator (tPA) is a more rapid and effective agent than streptokinase for peripheral thrombolysis. Twenty-three patients with acute limb-threatening ischaemia treated with tPA (0.5 mg h-1) over 15 months were compared with 20 consecutive patients previously receiving streptokinase (5000-10,000 units h-1). There were no major differences between the rates of complete and partial lysis (61 per cent for tPA versus 65 per cent for streptokinase) or limb salvage (65 versus 55 per cent respectively). Complication rates were also similar. It was not possible to show that tPA, an agent ten times more expensive than streptokinase, was superior for peripheral thrombolysis.
| Errataetall: | |
|---|---|
| Medienart: |
Artikel |
| Erscheinungsjahr: |
1993 |
|---|---|
| Erschienen: |
1993 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:80 |
|---|---|
| Enthalten in: |
The British journal of surgery - 80(1993), 1 vom: 15. Jan., Seite 25-7 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Earnshaw, J J [VerfasserIn] |
|---|
| Themen: |
EC 3.4.- |
|---|
| Anmerkungen: |
Date Completed 08.03.1993 Date Revised 05.07.2019 published: Print CommentIn: Br J Surg. 1993 Jun;80(6):808. - PMID 8330183 Citation Status MEDLINE |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
NLM084028742 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM084028742 | ||
| 003 | DE-627 | ||
| 005 | 20231222060422.0 | ||
| 007 | tu | ||
| 008 | 231222s1993 xx ||||| 00| ||eng c | ||
| 028 | 5 | 2 | |a pubmed24n0280.xml |
| 035 | |a (DE-627)NLM084028742 | ||
| 035 | |a (NLM)8428284 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Earnshaw, J J |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Choice of agent for peripheral thrombolysis |
| 264 | 1 | |c 1993 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 08.03.1993 | ||
| 500 | |a Date Revised 05.07.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a CommentIn: Br J Surg. 1993 Jun;80(6):808. - PMID 8330183 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Evidence has been accumulating that tissue plasminogen activator (tPA) is a more rapid and effective agent than streptokinase for peripheral thrombolysis. Twenty-three patients with acute limb-threatening ischaemia treated with tPA (0.5 mg h-1) over 15 months were compared with 20 consecutive patients previously receiving streptokinase (5000-10,000 units h-1). There were no major differences between the rates of complete and partial lysis (61 per cent for tPA versus 65 per cent for streptokinase) or limb salvage (65 versus 55 per cent respectively). Complication rates were also similar. It was not possible to show that tPA, an agent ten times more expensive than streptokinase, was superior for peripheral thrombolysis | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Streptokinase |2 NLM | |
| 650 | 7 | |a EC 3.4.- |2 NLM | |
| 650 | 7 | |a Tissue Plasminogen Activator |2 NLM | |
| 650 | 7 | |a EC 3.4.21.68 |2 NLM | |
| 700 | 1 | |a Scott, D J |e verfasserin |4 aut | |
| 700 | 1 | |a Horrocks, M |e verfasserin |4 aut | |
| 700 | 1 | |a Baird, R N |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The British journal of surgery |d 1945 |g 80(1993), 1 vom: 15. Jan., Seite 25-7 |w (DE-627)NLM000001465 |x 1365-2168 |7 nnns |
| 773 | 1 | 8 | |g volume:80 |g year:1993 |g number:1 |g day:15 |g month:01 |g pages:25-7 |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 80 |j 1993 |e 1 |b 15 |c 01 |h 25-7 | ||