Experimental and clinical studies of temafloxacin in the field of obstetrics and gynecology
Temafloxacin (TMFX, TA-167) is a new quinolone antimicrobial agent that has a broad antibacterial spectrum against Gram-positive, Gram-negative and anaerobic bacteria. We obtained the following results from laboratory and clinical studies on TMFX. 1. TMFX showed good penetration into the female genital organs and Cmax's in various organs were 2.77-4.24 micrograms/g when 300 mg was administered, and these values were equal to or higher than Cmax in vein blood. 2. The clinical efficacy rate was 95.4% in a clinical study involving 219 cases. The bacterial eradication rate was 96.4% in 139 cases. 3. Nine cases of side effects and 1 case of abnormal change in laboratory findings were noted in 254 cases involved, but none of them was serious. Based on these findings, TMFX is expected to be a useful antimicrobial agent for the treatment of obstetric and gynecological infections.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
1993 |
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| Erschienen: |
1993 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:46 |
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| Enthalten in: |
The Japanese journal of antibiotics - 46(1993), 6 vom: 15. Juni, Seite 492-504 |
| Sprache: |
Japanisch |
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| Beteiligte Personen: |
Matsuda, S [VerfasserIn] |
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| Themen: |
1WZ12GTT67 |
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| Anmerkungen: |
Date Completed 28.09.1993 Date Revised 16.11.2016 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM083703500 |
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| 100 | 1 | |a Matsuda, S |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Experimental and clinical studies of temafloxacin in the field of obstetrics and gynecology |
| 264 | 1 | |c 1993 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 28.09.1993 | ||
| 500 | |a Date Revised 16.11.2016 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Temafloxacin (TMFX, TA-167) is a new quinolone antimicrobial agent that has a broad antibacterial spectrum against Gram-positive, Gram-negative and anaerobic bacteria. We obtained the following results from laboratory and clinical studies on TMFX. 1. TMFX showed good penetration into the female genital organs and Cmax's in various organs were 2.77-4.24 micrograms/g when 300 mg was administered, and these values were equal to or higher than Cmax in vein blood. 2. The clinical efficacy rate was 95.4% in a clinical study involving 219 cases. The bacterial eradication rate was 96.4% in 139 cases. 3. Nine cases of side effects and 1 case of abnormal change in laboratory findings were noted in 254 cases involved, but none of them was serious. Based on these findings, TMFX is expected to be a useful antimicrobial agent for the treatment of obstetric and gynecological infections | ||
| 650 | 4 | |a Clinical Trial | |
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 7 | |a Anti-Infective Agents |2 NLM | |
| 650 | 7 | |a Fluoroquinolones |2 NLM | |
| 650 | 7 | |a Quinolones |2 NLM | |
| 650 | 7 | |a temafloxacin |2 NLM | |
| 650 | 7 | |a 1WZ12GTT67 |2 NLM | |
| 700 | 1 | |a Shimizu, T |e verfasserin |4 aut | |
| 700 | 1 | |a Cho, N |e verfasserin |4 aut | |
| 700 | 1 | |a Okada, H |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The Japanese journal of antibiotics |d 1968 |g 46(1993), 6 vom: 15. Juni, Seite 492-504 |w (DE-627)NLM000052434 |x 0368-2781 |7 nnns |
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| 952 | |d 46 |j 1993 |e 6 |b 15 |c 06 |h 492-504 | ||