Elevated tyrosine hydroxylase mRNA levels in the adrenal medulla of spontaneously hypertensive rats
We investigated the expression of tyrosine hydroxylase (TH) mRNA and its activity in the adrenal medulla of spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY). The TH mRNA levels were determined by Northern blot and dot blot analyses. The TH activity and the expression of TH mRNA in the adrenal medulla of SHR were significantly higher than those of WKY (P < 0.01). These results suggested that the hypertension of SHR may be related to the high activity of TH due to the high level of TH mRNA, which increases epinephrine and norepinephrine levels in the adrenal medulla.
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
1994 |
|---|---|
| Erschienen: |
1994 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:65 |
|---|---|
| Enthalten in: |
Japanese journal of pharmacology - 65(1994), 4 vom: 28. Aug., Seite 367-9 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Kumai, T [VerfasserIn] |
|---|
| Themen: |
EC 1.14.16.2 |
|---|
| Anmerkungen: |
Date Completed 06.01.1995 Date Revised 25.07.2019 published: Print Citation Status MEDLINE |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
NLM079656110 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM079656110 | ||
| 003 | DE-627 | ||
| 005 | 20231222042655.0 | ||
| 007 | tu | ||
| 008 | 231222s1994 xx ||||| 00| ||eng c | ||
| 028 | 5 | 2 | |a pubmed24n0266.xml |
| 035 | |a (DE-627)NLM079656110 | ||
| 035 | |a (NLM)7990274 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Kumai, T |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Elevated tyrosine hydroxylase mRNA levels in the adrenal medulla of spontaneously hypertensive rats |
| 264 | 1 | |c 1994 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 06.01.1995 | ||
| 500 | |a Date Revised 25.07.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a We investigated the expression of tyrosine hydroxylase (TH) mRNA and its activity in the adrenal medulla of spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY). The TH mRNA levels were determined by Northern blot and dot blot analyses. The TH activity and the expression of TH mRNA in the adrenal medulla of SHR were significantly higher than those of WKY (P < 0.01). These results suggested that the hypertension of SHR may be related to the high activity of TH due to the high level of TH mRNA, which increases epinephrine and norepinephrine levels in the adrenal medulla | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a RNA, Messenger |2 NLM | |
| 650 | 7 | |a Tyrosine 3-Monooxygenase |2 NLM | |
| 650 | 7 | |a EC 1.14.16.2 |2 NLM | |
| 650 | 7 | |a Norepinephrine |2 NLM | |
| 650 | 7 | |a X4W3ENH1CV |2 NLM | |
| 650 | 7 | |a Epinephrine |2 NLM | |
| 650 | 7 | |a YKH834O4BH |2 NLM | |
| 700 | 1 | |a Tanaka, M |e verfasserin |4 aut | |
| 700 | 1 | |a Watanabe, M |e verfasserin |4 aut | |
| 700 | 1 | |a Kobayashi, S |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Japanese journal of pharmacology |d 1952 |g 65(1994), 4 vom: 28. Aug., Seite 367-9 |w (DE-627)NLM00001995X |x 0021-5198 |7 nnns |
| 773 | 1 | 8 | |g volume:65 |g year:1994 |g number:4 |g day:28 |g month:08 |g pages:367-9 |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 65 |j 1994 |e 4 |b 28 |c 08 |h 367-9 | ||