Peripheral microchimerism in long-term cadaveric-kidney allograft recipients
Microchimerism after allogeneic organ transplantation may be a mechanism for induction of donor-specific graft acceptance. However, the frequency of chimerism and its relevance in long-term tolerance are uncertain. We studied 15 long-surviving (more than 20 years) cadaveric-kidney transplant recipients for the systemic presence of donor alleles with allele-specific genomic amplification of DRB1 and H-Y loci. Microchimerism was observed in 1 case in peripheral blood and in 4 cases in skin. Chimerism and number of HLA alleles shared by donor and recipient were not correlated. This low frequency of microchimerism in long-term kidney allograft recipients raises doubts about a major participation of chimerism in donor-specific tolerance.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
1994 |
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| Erschienen: |
1994 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:343 |
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| Enthalten in: |
Lancet (London, England) - 343(1994), 8911 vom: 11. Juni, Seite 1468-9 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Suberbielle, C [VerfasserIn] |
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| Themen: |
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| Anmerkungen: |
Date Completed 05.07.1994 Date Revised 11.06.2019 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM078865212 |
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| 245 | 1 | 0 | |a Peripheral microchimerism in long-term cadaveric-kidney allograft recipients |
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| 500 | |a Date Completed 05.07.1994 | ||
| 500 | |a Date Revised 11.06.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Microchimerism after allogeneic organ transplantation may be a mechanism for induction of donor-specific graft acceptance. However, the frequency of chimerism and its relevance in long-term tolerance are uncertain. We studied 15 long-surviving (more than 20 years) cadaveric-kidney transplant recipients for the systemic presence of donor alleles with allele-specific genomic amplification of DRB1 and H-Y loci. Microchimerism was observed in 1 case in peripheral blood and in 4 cases in skin. Chimerism and number of HLA alleles shared by donor and recipient were not correlated. This low frequency of microchimerism in long-term kidney allograft recipients raises doubts about a major participation of chimerism in donor-specific tolerance | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Kreis, H |e verfasserin |4 aut | |
| 700 | 1 | |a Bach, J F |e verfasserin |4 aut | |
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