Acteoside, a component of Stachys sieboldii MIQ, may be a promising antinephritic agent (2) : Effect of acteoside on leukocyte accumulation in the glomeruli of nephritic rats
We investigated the effect of acteoside in comparison with that of cyclosporin A on leukocyte accumulation in the glomeruli of rats with crescentic-type anti-glomerular basement membrane (GBM) nephritis. Acteoside given p.o. at a dose of 30 mg/kg once a day for 15 consecutive days after treatment with anti-GBM serum markedly suppressed the urinary protein as well as glomerular histological changes. Acteoside given p.o. for 5 or 15 consecutive days markedly suppressed the accumulation of total leukocytes, ED-1-positive cells (monocytes/macrophages), CD4-positive cells, CD8-positive cells, interleukin-2-receptor-positive cells (activated T cells) and Ia-positive cells in the glomeruli. These effects of cyclosporin A (20 mg/kg/day, p.o.) were also as potent as those of acteoside (30 mg/kg/day, p.o.). Cyclosporin A also strongly suppressed the elevation of plasma antibody level against rabbit gamma-globulin. However, in this dose, acteoside did not significantly suppress the antibody formation. It can be concluded from these results that acetoside may exert its antinephritic action by suppressing the accumulation of leukocytes in the glomeruli.
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
1994 |
|---|---|
| Erschienen: |
1994 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:66 |
|---|---|
| Enthalten in: |
Japanese journal of pharmacology - 66(1994), 1 vom: 08. Sept., Seite 47-52 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Hayashi, K [VerfasserIn] |
|---|
| Themen: |
3TGX09BD5B |
|---|
| Anmerkungen: |
Date Completed 21.03.1995 Date Revised 25.07.2019 published: Print Citation Status MEDLINE |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
NLM075083795 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM075083795 | ||
| 003 | DE-627 | ||
| 005 | 20231222024225.0 | ||
| 007 | tu | ||
| 008 | 231222s1994 xx ||||| 00| ||eng c | ||
| 028 | 5 | 2 | |a pubmed24n0251.xml |
| 035 | |a (DE-627)NLM075083795 | ||
| 035 | |a (NLM)7532244 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Hayashi, K |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Acteoside, a component of Stachys sieboldii MIQ, may be a promising antinephritic agent (2) |b Effect of acteoside on leukocyte accumulation in the glomeruli of nephritic rats |
| 264 | 1 | |c 1994 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 21.03.1995 | ||
| 500 | |a Date Revised 25.07.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a We investigated the effect of acteoside in comparison with that of cyclosporin A on leukocyte accumulation in the glomeruli of rats with crescentic-type anti-glomerular basement membrane (GBM) nephritis. Acteoside given p.o. at a dose of 30 mg/kg once a day for 15 consecutive days after treatment with anti-GBM serum markedly suppressed the urinary protein as well as glomerular histological changes. Acteoside given p.o. for 5 or 15 consecutive days markedly suppressed the accumulation of total leukocytes, ED-1-positive cells (monocytes/macrophages), CD4-positive cells, CD8-positive cells, interleukin-2-receptor-positive cells (activated T cells) and Ia-positive cells in the glomeruli. These effects of cyclosporin A (20 mg/kg/day, p.o.) were also as potent as those of acteoside (30 mg/kg/day, p.o.). Cyclosporin A also strongly suppressed the elevation of plasma antibody level against rabbit gamma-globulin. However, in this dose, acteoside did not significantly suppress the antibody formation. It can be concluded from these results that acetoside may exert its antinephritic action by suppressing the accumulation of leukocytes in the glomeruli | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Glucosides |2 NLM | |
| 650 | 7 | |a Immunosuppressive Agents |2 NLM | |
| 650 | 7 | |a Phenols |2 NLM | |
| 650 | 7 | |a gamma-Globulins |2 NLM | |
| 650 | 7 | |a acteoside |2 NLM | |
| 650 | 7 | |a 3TGX09BD5B |2 NLM | |
| 650 | 7 | |a Cyclosporine |2 NLM | |
| 650 | 7 | |a 83HN0GTJ6D |2 NLM | |
| 700 | 1 | |a Nagamatsu, T |e verfasserin |4 aut | |
| 700 | 1 | |a Ito, M |e verfasserin |4 aut | |
| 700 | 1 | |a Hattori, T |e verfasserin |4 aut | |
| 700 | 1 | |a Suzuki, Y |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Japanese journal of pharmacology |d 1952 |g 66(1994), 1 vom: 08. Sept., Seite 47-52 |w (DE-627)NLM00001995X |x 0021-5198 |7 nnns |
| 773 | 1 | 8 | |g volume:66 |g year:1994 |g number:1 |g day:08 |g month:09 |g pages:47-52 |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 66 |j 1994 |e 1 |b 08 |c 09 |h 47-52 | ||