Bacterial [Cu,Zn]-superoxide dismutase : phylogenetically distinct from the eukaryotic enzyme, and not so rare after all!

Copper- and zinc-containing superoxide dismutases ([Cu,Zn]-SODs) are generally considered almost exclusively eukaryotic enzymes, protecting the cytosol and extracellular compartments of higher organisms from damage by oxygen free-radicals. The recent description of a few examples of bacterial forms of the enzyme, located in the periplasm of different Gram-negative micro-organisms, prompted a re-evaluation of this general perception. A PCR-based approach has been developed and used successfully to identify bacterial genes encoding [Cu,Zn]-SOD in a wide range of important human and animal pathogens-members of the Haemophilus, Actinobacillus and Pasteurella (HAP) group, and Neisseria meningitidis. Comparison of [Cu,Zn]-SOD peptide sequences found in Haemophilus ducreyi, Actinobacillus pleuropneumoniae, Actinobacillus actinomycetemcomitans, Pasteurella multocida, and N. meningitidis with previously described bacterial proteins and examples of eukaryotic [Cu,Zn]-SOD has shown that the bacterial proteins constitute a distinct family apparently widely separated in evolutionary terms from the eukaryotic examples. The widespread occurrence of [Cu,Zn]-SOD in the periplasm of bacterial pathogens, appropriately located to dismute exogenously derived superoxide radical anions, suggests that this enzyme may play a role in the interactive biology of organisms with their hosts and so contribute to their capacity to cause disease.

Medienart:

Artikel

Erscheinungsjahr:

1995

Erschienen:

1995

Enthalten in:

Zur Gesamtaufnahme - volume:141 ( Pt 9)

Enthalten in:

Microbiology (Reading, England) - 141 ( Pt 9)(1995) vom: 08. Sept., Seite 2271-9

Sprache:

Englisch

Beteiligte Personen:

Kroll, J S [VerfasserIn]
Langford, P R [VerfasserIn]
Wilks, K E [VerfasserIn]
Keil, A D [VerfasserIn]

Themen:

789U1901C5
Bacterial Proteins
Comparative Study
Copper
EC 1.15.1.1
J41CSQ7QDS
Journal Article
Research Support, Non-U.S. Gov't
Superoxide Dismutase
Zinc

Anmerkungen:

Date Completed 16.01.1996

Date Revised 26.08.2020

published: Print

GENBANK: X83122, X83123, X83124, X83125, X83126

Citation Status MEDLINE

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM074732048