Large bowel cancer in women in relation to reproductive and hormonal factors : a case-control study
A community-based case-control study of the effect of reproductive factors on risk of large bowel cancer in Australia is described. The study involved 155 cases (99 colon cancer, 56 rectal cancer) and 311 controls who were interviewed with regard to pregnancies and their outcomes, lactation, menstrual history, and oral contraceptive (OC) use. Increasing parity was associated with a decreasing risk of colon cancer; para 0, relative risk (RR)=1; para 1-2, RR=0.9, 95% confidence interval (CI)=0.4-1.8; para greater than or equal to 3, RR=0.4, 95% CI=0.2-0.8; later age at first live birth (AFLB) was associated with increasing risk (AFLB less than or equal to 21 yr, RR=1; 22-25 yr, RR=2.3, 95% CI=1.0-5.5; greater than or equal to 26 yr, RR=2.7, 95% CI=1.2-6.2). These effects were independent of each other. Parity appeared to exert its predominant effect on risk of cancer of the right colon. OC use was more common among controls than cases (RR=0.5; 95% CI=0.3-1.2 for ever vs. never users) and showed a dose-response effect in multiple logistic analysis. The pattern of point-estimate RR for rectal cancer was largely congruent with those for colon cancer but was not significantly different from 1.0.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
1983 |
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| Erschienen: |
1983 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:71 |
|---|---|
| Enthalten in: |
Journal of the National Cancer Institute - 71(1983), 4 vom: 28. Okt., Seite 703-9 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Potter, J D [VerfasserIn] |
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| Anmerkungen: |
Date Completed 23.11.1983 Date Revised 17.11.2004 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM06555308X |
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| 100 | 1 | |a Potter, J D |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Large bowel cancer in women in relation to reproductive and hormonal factors |b a case-control study |
| 264 | 1 | |c 1983 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 23.11.1983 | ||
| 500 | |a Date Revised 17.11.2004 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a A community-based case-control study of the effect of reproductive factors on risk of large bowel cancer in Australia is described. The study involved 155 cases (99 colon cancer, 56 rectal cancer) and 311 controls who were interviewed with regard to pregnancies and their outcomes, lactation, menstrual history, and oral contraceptive (OC) use. Increasing parity was associated with a decreasing risk of colon cancer; para 0, relative risk (RR)=1; para 1-2, RR=0.9, 95% confidence interval (CI)=0.4-1.8; para greater than or equal to 3, RR=0.4, 95% CI=0.2-0.8; later age at first live birth (AFLB) was associated with increasing risk (AFLB less than or equal to 21 yr, RR=1; 22-25 yr, RR=2.3, 95% CI=1.0-5.5; greater than or equal to 26 yr, RR=2.7, 95% CI=1.2-6.2). These effects were independent of each other. Parity appeared to exert its predominant effect on risk of cancer of the right colon. OC use was more common among controls than cases (RR=0.5; 95% CI=0.3-1.2 for ever vs. never users) and showed a dose-response effect in multiple logistic analysis. The pattern of point-estimate RR for rectal cancer was largely congruent with those for colon cancer but was not significantly different from 1.0 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Age Distribution | |
| 650 | 4 | |a Age Factors | |
| 650 | 4 | |a Biology | |
| 650 | 4 | |a Cancer--women | |
| 650 | 4 | |a Data Collection | |
| 650 | 4 | |a Demographic Factors | |
| 650 | 4 | |a Diseases | |
| 650 | 4 | |a Fertility | |
| 650 | 4 | |a Fertility Measurements | |
| 650 | 4 | |a Gastrointestinal Effects | |
| 650 | 4 | |a Incidence | |
| 650 | 4 | |a Marital Status | |
| 650 | 4 | |a Measurement | |
| 650 | 4 | |a Menopause | |
| 650 | 4 | |a Neoplasms | |
| 650 | 4 | |a Occupations | |
| 650 | 4 | |a Parity | |
| 650 | 4 | |a Physiology | |
| 650 | 4 | |a Population | |
| 650 | 4 | |a Population At Risk | |
| 650 | 4 | |a Population Characteristics | |
| 650 | 4 | |a Population Dynamics | |
| 650 | 4 | |a Research Methodology | |
| 700 | 1 | |a McMichael, A J |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of the National Cancer Institute |d 1945 |g 71(1983), 4 vom: 28. Okt., Seite 703-9 |w (DE-627)NLM000019747 |x 1460-2105 |7 nnns |
| 773 | 1 | 8 | |g volume:71 |g year:1983 |g number:4 |g day:28 |g month:10 |g pages:703-9 |
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| 951 | |a AR | ||
| 952 | |d 71 |j 1983 |e 4 |b 28 |c 10 |h 703-9 | ||