Toxicity and association of polycyanoacrylate nanoparticles with hepatocytes
The degradation of polybutylcyanoacrylate (PBC) and polyhexylcyanoacrylate (PHC) nanoparticles, together with their association with and toxicity towards isolated hepatocytes, were determined. Nanoparticles were not taken up by rat hepatocytes at a significant level. The LD50S of PBC and PHC nanoparticles towards hepatocytes were 0.4 mg/2 x 10(6) cells and greater than 1 mg/2 x 10(6) cells respectively. This hepatocyte toxicity cannot be attributed solely to the formaldehyde formed during degradation.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
1984 |
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| Erschienen: |
1984 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:1 |
|---|---|
| Enthalten in: |
Journal of microencapsulation - 1(1984), 3 vom: 22. Juli, Seite 253-7 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Kreuter, J [VerfasserIn] |
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| Anmerkungen: |
Date Completed 27.06.1989 Date Revised 20.11.2014 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM064208478 |
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| 100 | 1 | |a Kreuter, J |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Toxicity and association of polycyanoacrylate nanoparticles with hepatocytes |
| 264 | 1 | |c 1984 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 27.06.1989 | ||
| 500 | |a Date Revised 20.11.2014 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The degradation of polybutylcyanoacrylate (PBC) and polyhexylcyanoacrylate (PHC) nanoparticles, together with their association with and toxicity towards isolated hepatocytes, were determined. Nanoparticles were not taken up by rat hepatocytes at a significant level. The LD50S of PBC and PHC nanoparticles towards hepatocytes were 0.4 mg/2 x 10(6) cells and greater than 1 mg/2 x 10(6) cells respectively. This hepatocyte toxicity cannot be attributed solely to the formaldehyde formed during degradation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Cyanoacrylates |2 NLM | |
| 650 | 7 | |a Drug Carriers |2 NLM | |
| 650 | 7 | |a Organometallic Compounds |2 NLM | |
| 650 | 7 | |a Polymers |2 NLM | |
| 650 | 7 | |a indium oxine |2 NLM | |
| 650 | 7 | |a 14514-42-2 |2 NLM | |
| 650 | 7 | |a Formaldehyde |2 NLM | |
| 650 | 7 | |a 1HG84L3525 |2 NLM | |
| 650 | 7 | |a poly(hexyl-2-cyanoacrylate) |2 NLM | |
| 650 | 7 | |a 26877-39-4 |2 NLM | |
| 650 | 7 | |a Oxyquinoline |2 NLM | |
| 650 | 7 | |a 5UTX5635HP |2 NLM | |
| 650 | 7 | |a Enbucrilate |2 NLM | |
| 650 | 7 | |a F8CEP82QNP |2 NLM | |
| 700 | 1 | |a Wilson, C G |e verfasserin |4 aut | |
| 700 | 1 | |a Fry, J R |e verfasserin |4 aut | |
| 700 | 1 | |a Paterson, P |e verfasserin |4 aut | |
| 700 | 1 | |a Ratcliffe, J H |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of microencapsulation |d 1989 |g 1(1984), 3 vom: 22. Juli, Seite 253-7 |w (DE-627)NLM013098217 |x 1464-5246 |7 nnns |
| 773 | 1 | 8 | |g volume:1 |g year:1984 |g number:3 |g day:22 |g month:07 |g pages:253-7 |
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