Antibacterial nitroacridine, Nitroakridin 3582 : effects on bacterial growth and macromolecular biosynthesis in vivo
The antibacterial drug Nitroakridin 3582 inhibited the growth of selected grampositive bacteria more strongly than it inhibited the growth of gram-negative bacilli. Nitroakridin at concentrations of the order of 5 x 10(-5)m induced lysis of Bacillus licheniformis and Micrococcus lysodeikticus. At concentrations less than 10(-4)m, Nitroakridin 3582 reduced the exponential growth rate of Escherichia coli C-2; at 10(-4)m the drug was bacteriostatic, and, at concentrations greater than 10(-4)m, it was bactericidal. Prolonged bacteriostasis resulted in the formation of long filaments by E. coli, Serratia marcescens, Shigella sonnei, and Proteus mirabilis. The reversible effects of Nitroakridin 3582 on the growth of E. coli correlated with partial inhibitions of deoxyribonucleic acid biosynthesis; ribonucleic acid and protein syntheses were inhibited less strongly. Nitroakridin 3582 at concentrations greater than 2 x 10(-4)m, which block deoxyribonucleic acid biosynthesis, produced an accelerated bactericidal action.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
1971 |
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| Erschienen: |
1971 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:108 |
|---|---|
| Enthalten in: |
Journal of bacteriology - 108(1971), 1 vom: 13. Okt., Seite 320-7 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wolfe, A D [VerfasserIn] |
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| Anmerkungen: |
Date Completed 02.02.1972 Date Revised 26.05.2021 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM049210181 |
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|---|---|---|---|
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| 008 | 231221s1971 xx ||||| 00| ||eng c | ||
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| 041 | |a eng | ||
| 100 | 1 | |a Wolfe, A D |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Antibacterial nitroacridine, Nitroakridin 3582 |b effects on bacterial growth and macromolecular biosynthesis in vivo |
| 264 | 1 | |c 1971 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 02.02.1972 | ||
| 500 | |a Date Revised 26.05.2021 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The antibacterial drug Nitroakridin 3582 inhibited the growth of selected grampositive bacteria more strongly than it inhibited the growth of gram-negative bacilli. Nitroakridin at concentrations of the order of 5 x 10(-5)m induced lysis of Bacillus licheniformis and Micrococcus lysodeikticus. At concentrations less than 10(-4)m, Nitroakridin 3582 reduced the exponential growth rate of Escherichia coli C-2; at 10(-4)m the drug was bacteriostatic, and, at concentrations greater than 10(-4)m, it was bactericidal. Prolonged bacteriostasis resulted in the formation of long filaments by E. coli, Serratia marcescens, Shigella sonnei, and Proteus mirabilis. The reversible effects of Nitroakridin 3582 on the growth of E. coli correlated with partial inhibitions of deoxyribonucleic acid biosynthesis; ribonucleic acid and protein syntheses were inhibited less strongly. Nitroakridin 3582 at concentrations greater than 2 x 10(-4)m, which block deoxyribonucleic acid biosynthesis, produced an accelerated bactericidal action | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Acridines |2 NLM | |
| 650 | 7 | |a Anti-Bacterial Agents |2 NLM | |
| 650 | 7 | |a Bacterial Proteins |2 NLM | |
| 650 | 7 | |a Carbon Isotopes |2 NLM | |
| 650 | 7 | |a Culture Media |2 NLM | |
| 650 | 7 | |a DNA, Bacterial |2 NLM | |
| 650 | 7 | |a Nitro Compounds |2 NLM | |
| 650 | 7 | |a RNA, Bacterial |2 NLM | |
| 650 | 7 | |a Isoleucine |2 NLM | |
| 650 | 7 | |a 04Y7590D77 |2 NLM | |
| 650 | 7 | |a Phenylalanine |2 NLM | |
| 650 | 7 | |a 47E5O17Y3R |2 NLM | |
| 650 | 7 | |a Uracil |2 NLM | |
| 650 | 7 | |a 56HH86ZVCT |2 NLM | |
| 650 | 7 | |a Thymidine |2 NLM | |
| 650 | 7 | |a VC2W18DGKR |2 NLM | |
| 700 | 1 | |a Cook, T M |e verfasserin |4 aut | |
| 700 | 1 | |a Hahn, F E |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of bacteriology |d 1916 |g 108(1971), 1 vom: 13. Okt., Seite 320-7 |w (DE-627)NLM000004723 |x 1098-5530 |7 nnns |
| 773 | 1 | 8 | |g volume:108 |g year:1971 |g number:1 |g day:13 |g month:10 |g pages:320-7 |
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| 951 | |a AR | ||
| 952 | |d 108 |j 1971 |e 1 |b 13 |c 10 |h 320-7 | ||