Acetate and fluoroacetate as possible markers for glial metabolism in vivo
[3H]Acetate has been shown by light autoradiographic methods to label the neuropil but not the perikarya in brain and retina. [3H]Fluoroacetate behaves similarly. The study provides anatomical data which support the concept of metabolic compartmentation of glutamic acid and associated metabolites previously derived from biochemical studies. It is suggested that these may be markers of non-neuronal metabolism, probably mostly glial, and may be used to develop procedures which will provide complementary data to that obtained with 2-deoxyglucose on regional metabolism in brain.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
1986 |
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| Erschienen: |
1986 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:380 |
|---|---|
| Enthalten in: |
Brain research - 380(1986), 2 vom: 20. Aug., Seite 336-40 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Muir, D [VerfasserIn] |
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| Themen: |
Acetates |
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| Anmerkungen: |
Date Completed 18.11.1986 Date Revised 18.10.2021 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM037377396 |
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| 100 | 1 | |a Muir, D |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Acetate and fluoroacetate as possible markers for glial metabolism in vivo |
| 264 | 1 | |c 1986 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
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| 500 | |a Date Completed 18.11.1986 | ||
| 500 | |a Date Revised 18.10.2021 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a [3H]Acetate has been shown by light autoradiographic methods to label the neuropil but not the perikarya in brain and retina. [3H]Fluoroacetate behaves similarly. The study provides anatomical data which support the concept of metabolic compartmentation of glutamic acid and associated metabolites previously derived from biochemical studies. It is suggested that these may be markers of non-neuronal metabolism, probably mostly glial, and may be used to develop procedures which will provide complementary data to that obtained with 2-deoxyglucose on regional metabolism in brain | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Research Support, U.S. Gov't, P.H.S. | |
| 650 | 7 | |a Acetates |2 NLM | |
| 650 | 7 | |a Fluoroacetates |2 NLM | |
| 700 | 1 | |a Berl, S |e verfasserin |4 aut | |
| 700 | 1 | |a Clarke, D D |e verfasserin |4 aut | |
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