The alpha-adrenergic sensitivity of smooth muscle following sympathectomy
The effect of sympathetic nerve stimulation on postsynaptic alpha-adrenoceptors of cat's smooth muscle nictitating membrane was studied. L-noradrenaline, adrenaline, phenylephrine and clonidine caused a concentration-dependent contraction. In denervated tissue, the concentration-response curve for clonidine mainly shifted to the left in comparison with the control; in contrast to the innervated smooth muscle, there were no reliable differences between the constant dissociation Ka and KB for alpha 1- and alpha 2-selective and nonselective adrenomimetics and adrenoblockaders. The data obtained suggest alteration of pharmacological characteristics of smooth muscle alpha-adrenoceptors after interruption of the sympathetic nerve.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
1988 |
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| Erschienen: |
1988 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:74 |
|---|---|
| Enthalten in: |
Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova - 74(1988), 9 vom: 08. Sept., Seite 1287-93 |
| Sprache: |
Russisch |
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| Weiterer Titel: |
Al'fa-adrenergicheskaia chuvstvitel'nost' gladkoĭ myshtsy posle desimpatizatsii |
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| Beteiligte Personen: |
Telina, E N [VerfasserIn] |
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| Themen: |
Adrenergic alpha-Agonists |
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| Anmerkungen: |
Date Completed 01.03.1989 Date Revised 15.11.2006 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM028870069 |
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| 100 | 1 | |a Telina, E N |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The alpha-adrenergic sensitivity of smooth muscle following sympathectomy |
| 246 | 3 | 3 | |a Al'fa-adrenergicheskaia chuvstvitel'nost' gladkoĭ myshtsy posle desimpatizatsii |
| 264 | 1 | |c 1988 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 01.03.1989 | ||
| 500 | |a Date Revised 15.11.2006 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The effect of sympathetic nerve stimulation on postsynaptic alpha-adrenoceptors of cat's smooth muscle nictitating membrane was studied. L-noradrenaline, adrenaline, phenylephrine and clonidine caused a concentration-dependent contraction. In denervated tissue, the concentration-response curve for clonidine mainly shifted to the left in comparison with the control; in contrast to the innervated smooth muscle, there were no reliable differences between the constant dissociation Ka and KB for alpha 1- and alpha 2-selective and nonselective adrenomimetics and adrenoblockaders. The data obtained suggest alteration of pharmacological characteristics of smooth muscle alpha-adrenoceptors after interruption of the sympathetic nerve | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Adrenergic alpha-Agonists |2 NLM | |
| 650 | 7 | |a Adrenergic alpha-Antagonists |2 NLM | |
| 650 | 7 | |a Receptors, Adrenergic, alpha |2 NLM | |
| 700 | 1 | |a Khamitov, Kh S |e verfasserin |4 aut | |
| 700 | 1 | |a Akhmedzianov, R Kh |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova |d 1945 |g 74(1988), 9 vom: 08. Sept., Seite 1287-93 |w (DE-627)NLM00000331X |x 0015-329X |7 nnns |
| 773 | 1 | 8 | |g volume:74 |g year:1988 |g number:9 |g day:08 |g month:09 |g pages:1287-93 |
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| 952 | |d 74 |j 1988 |e 9 |b 08 |c 09 |h 1287-93 | ||