Prospective study of oral contraceptive use and risk of breast cancer in women
In 1976, 118,273 female nurses 30-55 years of age with no history of cancer completed a questionnaire regarding possible risk factors. By 1986, after 1,137,415 person-years of follow-up, we had documented 1,799 newly diagnosed cases of breast cancer. Compared with the risk of breast cancer for nonusers of oral contraceptives, the multivariate relative risks were 1.07 (95% confidence interval, 0.97-1.19) for all users, 1.06 (95% confidence interval, 0.96-1.18) for past users, and 1.53 (95% confidence interval, 1.06-2.19) for current users--women who used oral contraceptives up to 2 years before diagnosis of breast cancer. We conclude that overall past use of oral contraceptives is not associated with a substantial increase in the risk of breast cancer. Although we did not find women who used oral contraceptives before the first pregnancy to have an increased risk of breast cancer, the number of women who used oral contraceptives for a long duration in early reproductive life was too small to permit firm conclusions regarding the risk in this subgroup.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
1989 |
|---|---|
| Erschienen: |
1989 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:81 |
|---|---|
| Enthalten in: |
Journal of the National Cancer Institute - 81(1989), 17 vom: 06. Sept., Seite 1313-21 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Romieu, I [VerfasserIn] |
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| Anmerkungen: |
Date Completed 25.09.1989 Date Revised 10.05.2019 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM027511014 |
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| 041 | |a eng | ||
| 100 | 1 | |a Romieu, I |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Prospective study of oral contraceptive use and risk of breast cancer in women |
| 264 | 1 | |c 1989 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 25.09.1989 | ||
| 500 | |a Date Revised 10.05.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a In 1976, 118,273 female nurses 30-55 years of age with no history of cancer completed a questionnaire regarding possible risk factors. By 1986, after 1,137,415 person-years of follow-up, we had documented 1,799 newly diagnosed cases of breast cancer. Compared with the risk of breast cancer for nonusers of oral contraceptives, the multivariate relative risks were 1.07 (95% confidence interval, 0.97-1.19) for all users, 1.06 (95% confidence interval, 0.96-1.18) for past users, and 1.53 (95% confidence interval, 1.06-2.19) for current users--women who used oral contraceptives up to 2 years before diagnosis of breast cancer. We conclude that overall past use of oral contraceptives is not associated with a substantial increase in the risk of breast cancer. Although we did not find women who used oral contraceptives before the first pregnancy to have an increased risk of breast cancer, the number of women who used oral contraceptives for a long duration in early reproductive life was too small to permit firm conclusions regarding the risk in this subgroup | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, U.S. Gov't, P.H.S. | |
| 650 | 4 | |a Age Factors | |
| 650 | 4 | |a Alcohol Drinking | |
| 650 | 4 | |a Behavior | |
| 650 | 4 | |a Biology | |
| 650 | 4 | |a Breast Cancer | |
| 650 | 4 | |a Cancer | |
| 650 | 4 | |a Contraception | |
| 650 | 4 | |a Contraceptive Methods | |
| 650 | 4 | |a Delivery Of Health Care | |
| 650 | 4 | |a Demographic Factors | |
| 650 | 4 | |a Diseases | |
| 650 | 4 | |a Family And Household | |
| 650 | 4 | |a Family Characteristics | |
| 650 | 4 | |a Family Planning | |
| 650 | 4 | |a Female Contraception | |
| 650 | 4 | |a Fertility | |
| 650 | 4 | |a Fertility Measurements | |
| 650 | 4 | |a First Birth | |
| 650 | 4 | |a Health | |
| 650 | 4 | |a Health Personnel | |
| 650 | 4 | |a Histology | |
| 650 | 4 | |a Hormone Receptors--analysis | |
| 650 | 4 | |a Incidence | |
| 650 | 4 | |a Measurement | |
| 650 | 4 | |a Membrane Proteins | |
| 650 | 4 | |a Menarche | |
| 650 | 4 | |a Menopause | |
| 650 | 4 | |a Menstruation | |
| 650 | 4 | |a Neoplasms | |
| 650 | 4 | |a Nurses | |
| 650 | 4 | |a Oral Contraceptives | |
| 650 | 4 | |a Parity | |
| 650 | 4 | |a Physiology | |
| 650 | 4 | |a Population | |
| 650 | 4 | |a Population Characteristics | |
| 650 | 4 | |a Population Dynamics | |
| 650 | 4 | |a Pregnancy History | |
| 650 | 4 | |a Prospective Studies | |
| 650 | 4 | |a Reproduction | |
| 650 | 4 | |a Research Methodology | |
| 650 | 4 | |a Risk Factors | |
| 650 | 4 | |a Smoking | |
| 650 | 4 | |a Studies | |
| 650 | 7 | |a Contraceptives, Oral |2 NLM | |
| 700 | 1 | |a Willett, W C |e verfasserin |4 aut | |
| 700 | 1 | |a Colditz, G A |e verfasserin |4 aut | |
| 700 | 1 | |a Stampfer, M J |e verfasserin |4 aut | |
| 700 | 1 | |a Rosner, B |e verfasserin |4 aut | |
| 700 | 1 | |a Hennekens, C H |e verfasserin |4 aut | |
| 700 | 1 | |a Speizer, F E |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of the National Cancer Institute |d 1945 |g 81(1989), 17 vom: 06. Sept., Seite 1313-21 |w (DE-627)NLM000019747 |x 1460-2105 |7 nnns |
| 773 | 1 | 8 | |g volume:81 |g year:1989 |g number:17 |g day:06 |g month:09 |g pages:1313-21 |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 81 |j 1989 |e 17 |b 06 |c 09 |h 1313-21 | ||