A case-control study of large bowel cancer and hormone exposure in women
Several lines of evidence indicate a potential role for hormonal or reproductive factors in the subsequent development of large bowel cancer in women. To evaluate the relationship between hormone exposure and large bowel cancer a case-control study was carried out in 18 Illinois hospitals. Female cases, ages 45-74 (n = 90), and controls (n = 208) were identified from an ongoing large bowel cancer study. Data were obtained from medical records, personal interviews, and a subsequent mail survey with a questionnaire specific to hormone usage. Menopausal estrogen use was found to be protective with respect to the subsequent development of large bowel cancer with an odds ratio of 0.6 (95% CI, 0.33-0.99). This effect remained after controlling individually for age at diagnosis, ever pregnant (yes/no), parity, age at first birth, hysterectomy with documented oophorectomy, cholecystectomy, and appendectomy. Simultaneous adjustment, using logistic regression, for age at diagnosis, parity, hysterectomy, and cholecystectomy resulted in an adjusted odds ratio for menopausal estrogen use and large bowel cancer of 0.5 (95% CI, 0.27-0.90). Subsite analysis revealed the protective effect to be strongest for the rectal cancer cases. These data support the hypothesis that exogenous hormones may alter the risk of large bowel cancer in women.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
1989 |
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| Erschienen: |
1989 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:49 |
|---|---|
| Enthalten in: |
Cancer research - 49(1989), 17 vom: 01. Sept., Seite 4936-40 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Furner, S E [VerfasserIn] |
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| Anmerkungen: |
Date Completed 15.09.1989 Date Revised 15.11.2006 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM027397394 |
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| 100 | 1 | |a Furner, S E |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A case-control study of large bowel cancer and hormone exposure in women |
| 264 | 1 | |c 1989 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 15.09.1989 | ||
| 500 | |a Date Revised 15.11.2006 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Several lines of evidence indicate a potential role for hormonal or reproductive factors in the subsequent development of large bowel cancer in women. To evaluate the relationship between hormone exposure and large bowel cancer a case-control study was carried out in 18 Illinois hospitals. Female cases, ages 45-74 (n = 90), and controls (n = 208) were identified from an ongoing large bowel cancer study. Data were obtained from medical records, personal interviews, and a subsequent mail survey with a questionnaire specific to hormone usage. Menopausal estrogen use was found to be protective with respect to the subsequent development of large bowel cancer with an odds ratio of 0.6 (95% CI, 0.33-0.99). This effect remained after controlling individually for age at diagnosis, ever pregnant (yes/no), parity, age at first birth, hysterectomy with documented oophorectomy, cholecystectomy, and appendectomy. Simultaneous adjustment, using logistic regression, for age at diagnosis, parity, hysterectomy, and cholecystectomy resulted in an adjusted odds ratio for menopausal estrogen use and large bowel cancer of 0.5 (95% CI, 0.27-0.90). Subsite analysis revealed the protective effect to be strongest for the rectal cancer cases. These data support the hypothesis that exogenous hormones may alter the risk of large bowel cancer in women | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Adult | |
| 650 | 4 | |a Age Factors | |
| 650 | 4 | |a Biology | |
| 650 | 4 | |a Cancer | |
| 650 | 4 | |a Case Studies | |
| 650 | 4 | |a Contraception | |
| 650 | 4 | |a Contraceptive Methods | |
| 650 | 4 | |a Control Groups | |
| 650 | 4 | |a Cultural Background | |
| 650 | 4 | |a Demographic Factors | |
| 650 | 4 | |a Diseases | |
| 650 | 4 | |a Economic Factors | |
| 650 | 4 | |a Endocrine System | |
| 650 | 4 | |a Estrogens | |
| 650 | 4 | |a Ethnic Groups | |
| 650 | 4 | |a Family Planning | |
| 650 | 4 | |a Fertility | |
| 650 | 4 | |a Fertility Measurements | |
| 650 | 4 | |a Gastrointestinal Effects--etiology | |
| 650 | 4 | |a Hormones | |
| 650 | 4 | |a Menopause | |
| 650 | 4 | |a Middle Aged | |
| 650 | 4 | |a Neoplasms | |
| 650 | 4 | |a Oral Contraceptives | |
| 650 | 4 | |a Parity | |
| 650 | 4 | |a Physiology | |
| 650 | 4 | |a Population | |
| 650 | 4 | |a Population Characteristics | |
| 650 | 4 | |a Population Dynamics | |
| 650 | 4 | |a Reproduction | |
| 650 | 4 | |a Research Methodology | |
| 650 | 4 | |a Socioeconomic Factors | |
| 650 | 4 | |a Socioeconomic Status | |
| 650 | 4 | |a Studies | |
| 650 | 4 | |a Whites | |
| 650 | 7 | |a Contraceptives, Oral |2 NLM | |
| 650 | 7 | |a Estrogens |2 NLM | |
| 700 | 1 | |a Davis, F G |e verfasserin |4 aut | |
| 700 | 1 | |a Nelson, R L |e verfasserin |4 aut | |
| 700 | 1 | |a Haenszel, W |e verfasserin |4 aut | |
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