Therapy of chronic hepatitis B with recombinant human alpha and gamma interferon
Eight patients with chronic hepatitis B entered a pilot study of gamma interferon and alpha interferon in combination. Gamma interferon alone had minimal inhibitory effects on serum levels of hepatitis B virus as monitored by serum HBV DNA and DNA-polymerase activity. The drug also gave troublesome side effects. In contrast, alpha interferon had more potent inhibitory effects on serum HBV levels and fewer side effects. When combined, the two interferons showed no additive or synergistic effects in inhibiting serum levels of HBV DNA or DNA polymerase. These findings indicate that the addition of gamma interferon to alpha interferon provides no additional antiviral effects but contributes significantly to side effects.
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
1990 |
|---|---|
| Erschienen: |
1990 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
|---|---|
| Enthalten in: |
Hepatology (Baltimore, Md.) - 11(1990), 2 vom: 12. Feb., Seite 266-70 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Di Bisceglie, A M [VerfasserIn] |
|---|
| Themen: |
82115-62-6 |
|---|
| Anmerkungen: |
Date Completed 05.04.1990 Date Revised 28.08.2019 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM020878540 |
|---|
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| 100 | 1 | |a Di Bisceglie, A M |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Therapy of chronic hepatitis B with recombinant human alpha and gamma interferon |
| 264 | 1 | |c 1990 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 05.04.1990 | ||
| 500 | |a Date Revised 28.08.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Eight patients with chronic hepatitis B entered a pilot study of gamma interferon and alpha interferon in combination. Gamma interferon alone had minimal inhibitory effects on serum levels of hepatitis B virus as monitored by serum HBV DNA and DNA-polymerase activity. The drug also gave troublesome side effects. In contrast, alpha interferon had more potent inhibitory effects on serum HBV levels and fewer side effects. When combined, the two interferons showed no additive or synergistic effects in inhibiting serum levels of HBV DNA or DNA polymerase. These findings indicate that the addition of gamma interferon to alpha interferon provides no additional antiviral effects but contributes significantly to side effects | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Antiviral Agents |2 NLM | |
| 650 | 7 | |a DNA, Viral |2 NLM | |
| 650 | 7 | |a Interferon Type I |2 NLM | |
| 650 | 7 | |a Recombinant Proteins |2 NLM | |
| 650 | 7 | |a Interferon-gamma |2 NLM | |
| 650 | 7 | |a 82115-62-6 |2 NLM | |
| 650 | 7 | |a Alanine Transaminase |2 NLM | |
| 650 | 7 | |a EC 2.6.1.2 |2 NLM | |
| 650 | 7 | |a DNA-Directed DNA Polymerase |2 NLM | |
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| 700 | 1 | |a Rustgi, V K |e verfasserin |4 aut | |
| 700 | 1 | |a Kassianides, C |e verfasserin |4 aut | |
| 700 | 1 | |a Lisker-Melman, M |e verfasserin |4 aut | |
| 700 | 1 | |a Park, Y |e verfasserin |4 aut | |
| 700 | 1 | |a Waggoner, J G |e verfasserin |4 aut | |
| 700 | 1 | |a Hoofnagle, J H |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Hepatology (Baltimore, Md.) |d 1983 |g 11(1990), 2 vom: 12. Feb., Seite 266-70 |w (DE-627)NLM012603902 |x 1527-3350 |7 nnns |
| 773 | 1 | 8 | |g volume:11 |g year:1990 |g number:2 |g day:12 |g month:02 |g pages:266-70 |
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