Sequential morphologic changes of elastase-induced pulmonary emphysema in pig lungs. Evaluation by high-resolution computed tomography
The authors evaluated the early morphologic changes of elastase-induced pulmonary emphysema in the pig and correlated the findings with high-resolution computed tomography (HRCT). Nine Yorkshire pigs were included in this investigation; in seven, pulmonary emphysema was induced by 2 mg/kg body weight of elastase instilled selectively into the left lower lobe bronchus. Animals were studied by CT at 0, 1, 2, 3, 7, 14, and 21 days. At the completion of the experiment, the lungs were removed, inflated, fixed and dried, and subsequently sliced corresponding to the CT sections. The gross appearance, histologic appearance, and HRCT were correlated. On HRCT, sequential changes from early edema to development of emphysema were noted. Panlobular, centrilobular and paraseptal emphysema were observed. Elastase-induced pulmonary emphysema in the pig is a useful and reproducible animal model, and high-resolution computed tomography depicts the morphologic changes observed both by gross pathologic observations and histologic observations.
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
1991 |
|---|---|
| Erschienen: |
1991 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:26 |
|---|---|
| Enthalten in: |
Investigative radiology - 26(1991), 5 vom: 20. Mai, Seite 446-53 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Noma, S [VerfasserIn] |
|---|
| Themen: |
EC 3.4.21.36 |
|---|
| Anmerkungen: |
Date Completed 30.07.1991 Date Revised 20.08.2019 published: Print Citation Status MEDLINE |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
NLM020371195 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM020371195 | ||
| 003 | DE-627 | ||
| 005 | 20231221081240.0 | ||
| 007 | tu | ||
| 008 | 231221s1991 xx ||||| 00| ||eng c | ||
| 028 | 5 | 2 | |a pubmed24n0068.xml |
| 035 | |a (DE-627)NLM020371195 | ||
| 035 | |a (NLM)2055743 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Noma, S |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Sequential morphologic changes of elastase-induced pulmonary emphysema in pig lungs. Evaluation by high-resolution computed tomography |
| 264 | 1 | |c 1991 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 30.07.1991 | ||
| 500 | |a Date Revised 20.08.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The authors evaluated the early morphologic changes of elastase-induced pulmonary emphysema in the pig and correlated the findings with high-resolution computed tomography (HRCT). Nine Yorkshire pigs were included in this investigation; in seven, pulmonary emphysema was induced by 2 mg/kg body weight of elastase instilled selectively into the left lower lobe bronchus. Animals were studied by CT at 0, 1, 2, 3, 7, 14, and 21 days. At the completion of the experiment, the lungs were removed, inflated, fixed and dried, and subsequently sliced corresponding to the CT sections. The gross appearance, histologic appearance, and HRCT were correlated. On HRCT, sequential changes from early edema to development of emphysema were noted. Panlobular, centrilobular and paraseptal emphysema were observed. Elastase-induced pulmonary emphysema in the pig is a useful and reproducible animal model, and high-resolution computed tomography depicts the morphologic changes observed both by gross pathologic observations and histologic observations | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Pancreatic Elastase |2 NLM | |
| 650 | 7 | |a EC 3.4.21.36 |2 NLM | |
| 700 | 1 | |a Herman, P G |e verfasserin |4 aut | |
| 700 | 1 | |a Khan, A |e verfasserin |4 aut | |
| 700 | 1 | |a Rojas, K A |e verfasserin |4 aut | |
| 700 | 1 | |a Pipman, Y |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Investigative radiology |d 1966 |g 26(1991), 5 vom: 20. Mai, Seite 446-53 |w (DE-627)NLM000091014 |x 1536-0210 |7 nnns |
| 773 | 1 | 8 | |g volume:26 |g year:1991 |g number:5 |g day:20 |g month:05 |g pages:446-53 |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 26 |j 1991 |e 5 |b 20 |c 05 |h 446-53 | ||