Acute gluteal abscess following intramuscular chloroquine injection : a clinical and experimental study
This prospective study contains clinical and experimental parts. In the clinical study, 125 patients given intramuscular chloroquine for malaria were followed for 2 months in order to detect local injection site complications. Adequate local antiseptic conditions were ensured before giving the injection. Twenty-three patients (18.4%) had minimal local reaction in the form of redness, induration and/or a lump. No pyogenic abscess was noted in contrast to a previous report. In the second part of the study, an experimental animal (Green monkey) was given either chloroquine phosphate, Ampiclox or normal saline intramuscularly. The injection site was later biopsied and histologically examined. Intramuscular chloroquine was found to cause severe inflammatory reactions and muscle necrosis, whereas other injections had very minimal local effects. It is concluded that intramuscular chloroquine causes muscle necrosis which may lead to acute pyogenic abscess if minimal contamination takes place.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
1991 |
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| Erschienen: |
1991 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:94 |
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| Enthalten in: |
The Journal of tropical medicine and hygiene - 94(1991), 3 vom: 05. Juni, Seite 206-9 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
elZaki, K [VerfasserIn] |
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| Themen: |
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| Anmerkungen: |
Date Completed 23.07.1991 Date Revised 10.12.2019 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM020329199 |
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| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
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| 041 | |a eng | ||
| 100 | 1 | |a elZaki, K |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Acute gluteal abscess following intramuscular chloroquine injection |b a clinical and experimental study |
| 264 | 1 | |c 1991 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 23.07.1991 | ||
| 500 | |a Date Revised 10.12.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a This prospective study contains clinical and experimental parts. In the clinical study, 125 patients given intramuscular chloroquine for malaria were followed for 2 months in order to detect local injection site complications. Adequate local antiseptic conditions were ensured before giving the injection. Twenty-three patients (18.4%) had minimal local reaction in the form of redness, induration and/or a lump. No pyogenic abscess was noted in contrast to a previous report. In the second part of the study, an experimental animal (Green monkey) was given either chloroquine phosphate, Ampiclox or normal saline intramuscularly. The injection site was later biopsied and histologically examined. Intramuscular chloroquine was found to cause severe inflammatory reactions and muscle necrosis, whereas other injections had very minimal local effects. It is concluded that intramuscular chloroquine causes muscle necrosis which may lead to acute pyogenic abscess if minimal contamination takes place | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Chloroquine |2 NLM | |
| 650 | 7 | |a 886U3H6UFF |2 NLM | |
| 700 | 1 | |a Ahmed, M E |e verfasserin |4 aut | |
| 700 | 1 | |a elHassan, A M |e verfasserin |4 aut | |
| 700 | 1 | |a Yousif, M A |e verfasserin |4 aut | |
| 700 | 1 | |a Fahal, A H |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The Journal of tropical medicine and hygiene |d 1945-1946 |g 94(1991), 3 vom: 05. Juni, Seite 206-9 |w (DE-627)NLM000269360 |x 0022-5304 |7 nnns |
| 773 | 1 | 8 | |g volume:94 |g year:1991 |g number:3 |g day:05 |g month:06 |g pages:206-9 |
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| 951 | |a AR | ||
| 952 | |d 94 |j 1991 |e 3 |b 05 |c 06 |h 206-9 | ||