The characteristics of the interaction of the thyroliberin analog RGH 2202 and narcotic analgesics
The effect of an thyroliberin analogue RGH 2202 on respiration inhibition induced by narcotic analgetics and on their antinociceptive action was studied in experiments on mice, rabbits and rats. RGH 2202 (10 mg/kg, intravenously) was found to exert no effect on the antinociceptive effect of morphine in mice and rabbits. Meanwhile, RGH 2202 in doses of 1 to 5 mg/kg intravenously abolished the respiration inhibition induced by fentanyl (0.02-0.07 mg/kg, intravenously) or morphine (10 mg/kg, intravenously) in rabbits and rats. After administration of RGH 2202 in doses of 10-40 mg/kg intravenously no significant changes of arterial blood pressure or heart rate were observed. The results obtained suggest that RGH 2202 may be used for relieving the inhibitory effects of narcotic analgetics on the respiratory centre during intoxication with these agents and in anesthesiological practice.
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
1990 |
|---|---|
| Erschienen: |
1990 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:53 |
|---|---|
| Enthalten in: |
Farmakologiia i toksikologiia - 53(1990), 1 vom: 20. Jan., Seite 25-7 |
| Sprache: |
Russisch |
|---|
| Weiterer Titel: |
Osobennosti vzaimodeĭstviia analoga tiroliberina RGH 2202 i narkoticheskikh anal'getikov |
|---|
| Beteiligte Personen: |
Chichenkov, O N [VerfasserIn] |
|---|
| Themen: |
5Y5F15120W |
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| Anmerkungen: |
Date Completed 31.05.1990 Date Revised 21.11.2013 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM019516959 |
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| 100 | 1 | |a Chichenkov, O N |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The characteristics of the interaction of the thyroliberin analog RGH 2202 and narcotic analgesics |
| 246 | 3 | 3 | |a Osobennosti vzaimodeĭstviia analoga tiroliberina RGH 2202 i narkoticheskikh anal'getikov |
| 264 | 1 | |c 1990 | |
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| 500 | |a Date Completed 31.05.1990 | ||
| 500 | |a Date Revised 21.11.2013 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The effect of an thyroliberin analogue RGH 2202 on respiration inhibition induced by narcotic analgetics and on their antinociceptive action was studied in experiments on mice, rabbits and rats. RGH 2202 (10 mg/kg, intravenously) was found to exert no effect on the antinociceptive effect of morphine in mice and rabbits. Meanwhile, RGH 2202 in doses of 1 to 5 mg/kg intravenously abolished the respiration inhibition induced by fentanyl (0.02-0.07 mg/kg, intravenously) or morphine (10 mg/kg, intravenously) in rabbits and rats. After administration of RGH 2202 in doses of 10-40 mg/kg intravenously no significant changes of arterial blood pressure or heart rate were observed. The results obtained suggest that RGH 2202 may be used for relieving the inhibitory effects of narcotic analgetics on the respiratory centre during intoxication with these agents and in anesthesiological practice | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Analgesics, Opioid |2 NLM | |
| 650 | 7 | |a Thyrotropin-Releasing Hormone |2 NLM | |
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| 700 | 1 | |a Chizh, B A |e verfasserin |4 aut | |
| 700 | 1 | |a Bulaev, V M |e verfasserin |4 aut | |
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