Effect of estrogen on the blast transformation of lymphocytes and interleukin-2 production in lupus erythematosus
The mitogenic response of peripheral lymphocytes was investigated in 12 patients with systemic lupus erythematosus and in healthy female volunteers who were on 11 and without 9 contraceptive pills. The effect of estrogen (ethinyl-estradiol 10(-5)-10(-6)-10(-7)M) was studied on Phytohaemagglutinin and Pokeweed mitogen induced blastogenic transformation and interleukin-2 production of peripheral lymphocytes in vitro. We observed a significantly depressed Phytohaemagglutinin induced lymphoblastic transformation both in patients and women taking oral contraceptive in presence of 10(-5)M estrogen as compared to normal controls. However there was no significant alteration neither in the response of lymphocyte nor in the production of interleukin-2 using of Pokeweed mitogen. The stimulataneous inhibition of the interleukin-2 production proved to be moderate. Marked significant correlation (r greater than = 0.8) vas detected between lymphoblastic transformation and interleukin-2 production in healthy females. Correlation coefficient measured in females taking oral contraceptive (r less than = 0.64) and patients with systemic lupus erythematosus (r less than = 0.34) suggest that in these groups the inhibition of lymphoblastic transformation is due to the inhibition effect of estrogen on the interleukin-2 production.
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
1992 |
|---|---|
| Erschienen: |
1992 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:133 |
|---|---|
| Enthalten in: |
Orvosi hetilap - 133(1992), 19 vom: 10. Mai, Seite 1167-71 |
| Sprache: |
Ungarisch |
|---|
| Weiterer Titel: |
Oestrogen hatása a lymphocyta blastos transformatióra és az interleukin-2 termelésre systemás lupus erythematosusban |
|---|
| Beteiligte Personen: |
Pozsonyi, T [VerfasserIn] |
|---|
| Anmerkungen: |
Date Completed 16.06.1992 Date Revised 21.10.2009 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM015660931 |
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| 100 | 1 | |a Pozsonyi, T |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Effect of estrogen on the blast transformation of lymphocytes and interleukin-2 production in lupus erythematosus |
| 246 | 3 | 3 | |a Oestrogen hatása a lymphocyta blastos transformatióra és az interleukin-2 termelésre systemás lupus erythematosusban |
| 264 | 1 | |c 1992 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 16.06.1992 | ||
| 500 | |a Date Revised 21.10.2009 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The mitogenic response of peripheral lymphocytes was investigated in 12 patients with systemic lupus erythematosus and in healthy female volunteers who were on 11 and without 9 contraceptive pills. The effect of estrogen (ethinyl-estradiol 10(-5)-10(-6)-10(-7)M) was studied on Phytohaemagglutinin and Pokeweed mitogen induced blastogenic transformation and interleukin-2 production of peripheral lymphocytes in vitro. We observed a significantly depressed Phytohaemagglutinin induced lymphoblastic transformation both in patients and women taking oral contraceptive in presence of 10(-5)M estrogen as compared to normal controls. However there was no significant alteration neither in the response of lymphocyte nor in the production of interleukin-2 using of Pokeweed mitogen. The stimulataneous inhibition of the interleukin-2 production proved to be moderate. Marked significant correlation (r greater than = 0.8) vas detected between lymphoblastic transformation and interleukin-2 production in healthy females. Correlation coefficient measured in females taking oral contraceptive (r less than = 0.64) and patients with systemic lupus erythematosus (r less than = 0.34) suggest that in these groups the inhibition of lymphoblastic transformation is due to the inhibition effect of estrogen on the interleukin-2 production | ||
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Biology | |
| 650 | 4 | |a Contraception | |
| 650 | 4 | |a Contraceptive Agents, Estrogen--side effects | |
| 650 | 4 | |a Contraceptive Agents, Female--side effects | |
| 650 | 4 | |a Contraceptive Agents--side effects | |
| 650 | 4 | |a Contraceptive Methods--side effects | |
| 650 | 4 | |a Developed Countries | |
| 650 | 4 | |a Diseases | |
| 650 | 4 | |a Eastern Europe | |
| 650 | 4 | |a Ethinyl Estradiol--side effects | |
| 650 | 4 | |a Europe | |
| 650 | 4 | |a Family Planning | |
| 650 | 4 | |a Hematological Effects | |
| 650 | 4 | |a Hemic System | |
| 650 | 4 | |a Hungary | |
| 650 | 4 | |a Immunity | |
| 650 | 4 | |a Immunological Effects | |
| 650 | 4 | |a Oral Contraceptives, Combined--side effects | |
| 650 | 4 | |a Oral Contraceptives--side effects | |
| 650 | 4 | |a Physiology | |
| 650 | 4 | |a Systemic Lupus Erythematosus | |
| 650 | 7 | |a Contraceptives, Oral, Hormonal |2 NLM | |
| 650 | 7 | |a Estrogens |2 NLM | |
| 650 | 7 | |a Interleukin-2 |2 NLM | |
| 650 | 7 | |a Mitogens |2 NLM | |
| 700 | 1 | |a Jakab, L |e verfasserin |4 aut | |
| 700 | 1 | |a Jakab, L |e verfasserin |4 aut | |
| 700 | 1 | |a Onody, K |e verfasserin |4 aut | |
| 700 | 1 | |a Cseh, K |e verfasserin |4 aut | |
| 700 | 1 | |a Kalabay, L |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Orvosi hetilap |d 1949 |g 133(1992), 19 vom: 10. Mai, Seite 1167-71 |w (DE-627)NLM000021601 |x 1788-6120 |7 nnns |
| 773 | 1 | 8 | |g volume:133 |g year:1992 |g number:19 |g day:10 |g month:05 |g pages:1167-71 |
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| 951 | |a AR | ||
| 952 | |d 133 |j 1992 |e 19 |b 10 |c 05 |h 1167-71 | ||