Characterisation of NK receptors in guinea-pig urinary bladder smooth muscle : use of selective antagonists
The aim of the present study was to characterise the neurokinin receptors involved in mediating contractile responses in guinea-pig urinary bladder smooth muscle. The use of selective NK1, NK2, and NK3 receptor agonists indicated that contractile responses in this tissue are mediated via activation of NK1 and NK2, but not NK3 receptors. This was confirmed by the observation that responses to [Sar9,Met(O2)11]substance P were inhibited by (+/-)-CP 96,345 (a NK1 receptor antagonist) and responses to eledoisin (following NK1 receptor desensitization) were inhibited by L-659,877 (a NK2 receptor antagonist).
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
1992 |
|---|---|
| Erschienen: |
1992 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:222 |
|---|---|
| Enthalten in: |
European journal of pharmacology - 222(1992), 1 vom: 03. Nov., Seite 167-70 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Longmore, J [VerfasserIn] |
|---|
| Themen: |
110880-55-2 |
|---|
| Anmerkungen: |
Date Completed 22.01.1993 Date Revised 23.06.2019 published: Print Citation Status MEDLINE |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
NLM01262084X |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM01262084X | ||
| 003 | DE-627 | ||
| 005 | 20231221053112.0 | ||
| 007 | tu | ||
| 008 | 231221s1992 xx ||||| 00| ||eng c | ||
| 028 | 5 | 2 | |a pubmed24n0042.xml |
| 035 | |a (DE-627)NLM01262084X | ||
| 035 | |a (NLM)1281775 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Longmore, J |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Characterisation of NK receptors in guinea-pig urinary bladder smooth muscle |b use of selective antagonists |
| 264 | 1 | |c 1992 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 22.01.1993 | ||
| 500 | |a Date Revised 23.06.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The aim of the present study was to characterise the neurokinin receptors involved in mediating contractile responses in guinea-pig urinary bladder smooth muscle. The use of selective NK1, NK2, and NK3 receptor agonists indicated that contractile responses in this tissue are mediated via activation of NK1 and NK2, but not NK3 receptors. This was confirmed by the observation that responses to [Sar9,Met(O2)11]substance P were inhibited by (+/-)-CP 96,345 (a NK1 receptor antagonist) and responses to eledoisin (following NK1 receptor desensitization) were inhibited by L-659,877 (a NK2 receptor antagonist) | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Biphenyl Compounds |2 NLM | |
| 650 | 7 | |a Hypnotics and Sedatives |2 NLM | |
| 650 | 7 | |a Receptors, Neurotransmitter |2 NLM | |
| 650 | 7 | |a Receptors, Tachykinin |2 NLM | |
| 650 | 7 | |a substance P, Sar(9)-Met(O2)(11)- |2 NLM | |
| 650 | 7 | |a 110880-55-2 |2 NLM | |
| 650 | 7 | |a Substance P |2 NLM | |
| 650 | 7 | |a 33507-63-0 |2 NLM | |
| 650 | 7 | |a CP 96345 |2 NLM | |
| 650 | 7 | |a W22ILA2I52 |2 NLM | |
| 700 | 1 | |a Hill, R G |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t European journal of pharmacology |d 1967 |g 222(1992), 1 vom: 03. Nov., Seite 167-70 |w (DE-627)NLM000029769 |x 1879-0712 |7 nnns |
| 773 | 1 | 8 | |g volume:222 |g year:1992 |g number:1 |g day:03 |g month:11 |g pages:167-70 |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 222 |j 1992 |e 1 |b 03 |c 11 |h 167-70 | ||