The effect of ethane-1-hydroxy-1, 1-diphosphonic acid (EHDP) on matrix induced ectopic bone formation
The effect of diphosphonates (EHDP) was studied on induced ectopic osteoneogenesis. Decalcified allogeneic bone matrix was implanted into the lumbar muscles in rabbits for an ectopic osteoinductor. The ectopic new bone formation was studied under continuous EHDP administration and after discontinuation of EHDP. Although there was no inhibitory effect of EHDP on the osteoinduction, the calcification of the new bone and the resorption of the implanted matrix was retarded. The induced "osteoid-like" tissue had an atypical structure with a small number of cells and a deficiency in collagen fiber bundles. There were also large fields of new cartilage formation. Thus remodelling and mineralization were inhibited under the influence of continuous administration of EHDP. After discontinuation of EHDP administration a recovery phase was observed which seemed to lead to the formation of a normal ossicle.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
1978 |
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| Erschienen: |
1978 |
| Enthalten in: |
Zur Gesamtaufnahme - year:1978 |
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| Enthalten in: |
Clinical orthopaedics and related research - (1978), 132 vom: 15. Mai, Seite 233-43 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Plasmans, C M [VerfasserIn] |
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| Themen: |
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| Anmerkungen: |
Date Completed 25.10.1978 Date Revised 22.03.2017 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM000990787 |
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| 100 | 1 | |a Plasmans, C M |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The effect of ethane-1-hydroxy-1, 1-diphosphonic acid (EHDP) on matrix induced ectopic bone formation |
| 264 | 1 | |c 1978 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a Date Completed 25.10.1978 | ||
| 500 | |a Date Revised 22.03.2017 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The effect of diphosphonates (EHDP) was studied on induced ectopic osteoneogenesis. Decalcified allogeneic bone matrix was implanted into the lumbar muscles in rabbits for an ectopic osteoinductor. The ectopic new bone formation was studied under continuous EHDP administration and after discontinuation of EHDP. Although there was no inhibitory effect of EHDP on the osteoinduction, the calcification of the new bone and the resorption of the implanted matrix was retarded. The induced "osteoid-like" tissue had an atypical structure with a small number of cells and a deficiency in collagen fiber bundles. There were also large fields of new cartilage formation. Thus remodelling and mineralization were inhibited under the influence of continuous administration of EHDP. After discontinuation of EHDP administration a recovery phase was observed which seemed to lead to the formation of a normal ossicle | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Kuypers, W |e verfasserin |4 aut | |
| 700 | 1 | |a Slooff, T J |e verfasserin |4 aut | |
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