Oestrogen induced hypertriglyceridaemia : role of the adrenal cortex
The role of the adrenal cortex in the pathogenesis of hypertriglyceridaemia associated with the intake of oral contraceptive agents containing oestrogen has been investigated in rats. Bilateral adrenalectomy reduced the activity of hepatic enzymes regulating lipogenesis (acetyl CoA carboxylase, fatty acid synthetase) and decreased plasma triglyceride concentrations. On the other hand, the administration of high dosage corticosterone induced the activity of hepatic enzymes with consequent elevation in serum triglyceride levels. In animals with intact adrenals the administration of oestradiol: (a) raised plasma triglyceride levels, (b) enhanced the activity of hepatic enzymes, and (c) increased the adrenal cortex:body weight ratio. The effects (a) and (b) were not observed when both adrenals were removed prior to oestrogen therapy. High dosage corticosterone replacement was found to be essential for the oestradiol to produce its effects on hepatic enzymes and plasma triglyceride levels. The results suggest a regulatory role for the adrenal cortex in the homeostasis of plasma triglyceride concentration and that the hypertriglyceridaemia induced by the oestrogen containing preparations might be secondary to alterations in adrenocortical function.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
1976 |
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| Erschienen: |
1976 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:5 |
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| Enthalten in: |
Clinical endocrinology - 5(1976), 3 vom: 15. Mai, Seite 203-8 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Afolabi, S K [VerfasserIn] |
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| Themen: |
Acetyl-CoA Carboxylase |
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| Anmerkungen: |
Date Completed 29.10.1976 Date Revised 13.08.2019 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM000089125 |
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| 100 | 1 | |a Afolabi, S K |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Oestrogen induced hypertriglyceridaemia |b role of the adrenal cortex |
| 264 | 1 | |c 1976 | |
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| 500 | |a Date Completed 29.10.1976 | ||
| 500 | |a Date Revised 13.08.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The role of the adrenal cortex in the pathogenesis of hypertriglyceridaemia associated with the intake of oral contraceptive agents containing oestrogen has been investigated in rats. Bilateral adrenalectomy reduced the activity of hepatic enzymes regulating lipogenesis (acetyl CoA carboxylase, fatty acid synthetase) and decreased plasma triglyceride concentrations. On the other hand, the administration of high dosage corticosterone induced the activity of hepatic enzymes with consequent elevation in serum triglyceride levels. In animals with intact adrenals the administration of oestradiol: (a) raised plasma triglyceride levels, (b) enhanced the activity of hepatic enzymes, and (c) increased the adrenal cortex:body weight ratio. The effects (a) and (b) were not observed when both adrenals were removed prior to oestrogen therapy. High dosage corticosterone replacement was found to be essential for the oestradiol to produce its effects on hepatic enzymes and plasma triglyceride levels. The results suggest a regulatory role for the adrenal cortex in the homeostasis of plasma triglyceride concentration and that the hypertriglyceridaemia induced by the oestrogen containing preparations might be secondary to alterations in adrenocortical function | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Adrenal Cortex Hormones |2 NLM | |
| 650 | 7 | |a Estrogens |2 NLM | |
| 650 | 7 | |a Triglycerides |2 NLM | |
| 650 | 7 | |a Fatty Acid Synthases |2 NLM | |
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| 650 | 7 | |a Acetyl-CoA Carboxylase |2 NLM | |
| 650 | 7 | |a EC 6.4.1.2 |2 NLM | |
| 700 | 1 | |a Tulloch, B R |e verfasserin |4 aut | |
| 700 | 1 | |a Kissebah, A H |e verfasserin |4 aut | |
| 700 | 1 | |a Vydelingum, N |e verfasserin |4 aut | |
| 700 | 1 | |a Fraser, T R |e verfasserin |4 aut | |
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