Iron and insulin resistance
Background : Preliminary clinical and experimental results suggest that iron can modify hepatocytes’ insulin sensitivity by interfering with insulin receptor and intracellular insulin signalling.Aim : To evaluate in vivo the influence of iron on insulin resistance and insulin release in patients with non-alcoholic fatty liver disease and in vitro the interaction between iron and insulin sensitivity by analysing the effect of iron manipulation on insulin receptor expression in hepatoblastoma HepG2 cell line.Results : Insulin resistance evaluated by homeostatis model assessment (HOMA)-insulin resistance significantly decreased after diet, and a further reduction was observed after phlebotomies. Iron depletion by desferrioxamine increased by twofold the 125I-insulin-specific binding, whereas iron addition reduced insulin binding, similarly to cells exposed to high glucose concentration.Conclusion : Iron status affects insulin sensitivity by modulating the transcription and membrane expression/affinity of insulin receptor expression in hepatocytes and influencing insulin-dependent gene expression suggesting that increased insulin clearance and decreased insulin resistance may contribute to the positive effect of iron depletion in patients with non-alcoholic fatty liver disease..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2005 |
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| Erschienen: |
Oxford, UK: Blackwell Publishing Ltd ; 2005 |
| Reproduktion: |
2005 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
| Enthalten in: |
Alimentary pharmacology & therapeutics - 22(2005), Seite 0 |
| Beteiligte Personen: |
FARGION, S. [VerfasserIn] |
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| Links: |
Volltext [Deutschlandweit zugänglich] |
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| Umfang: |
Online-Ressource |
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| doi: |
10.1111/j.1365-2036.2005.02599.x |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLEJ242191460 |
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| 245 | 1 | 0 | |a Iron and insulin resistance |
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| 520 | |a Background : Preliminary clinical and experimental results suggest that iron can modify hepatocytes’ insulin sensitivity by interfering with insulin receptor and intracellular insulin signalling.Aim : To evaluate in vivo the influence of iron on insulin resistance and insulin release in patients with non-alcoholic fatty liver disease and in vitro the interaction between iron and insulin sensitivity by analysing the effect of iron manipulation on insulin receptor expression in hepatoblastoma HepG2 cell line.Results : Insulin resistance evaluated by homeostatis model assessment (HOMA)-insulin resistance significantly decreased after diet, and a further reduction was observed after phlebotomies. Iron depletion by desferrioxamine increased by twofold the 125I-insulin-specific binding, whereas iron addition reduced insulin binding, similarly to cells exposed to high glucose concentration.Conclusion : Iron status affects insulin sensitivity by modulating the transcription and membrane expression/affinity of insulin receptor expression in hepatocytes and influencing insulin-dependent gene expression suggesting that increased insulin clearance and decreased insulin resistance may contribute to the positive effect of iron depletion in patients with non-alcoholic fatty liver disease. | ||
| 533 | |d 2005 |f Blackwell Publishing Journal Backfiles 1879-2005 |7 |2005|||||||||| | ||
| 700 | 1 | |a DONGIOVANNI, P. |e verfasserin |4 aut | |
| 700 | 1 | |a GUZZO, A. |e verfasserin |4 aut | |
| 700 | 1 | |a COLOMBO, S. |4 oth | |
| 700 | 1 | |a VALENTI, L. |4 oth | |
| 700 | 1 | |a FRACANZANI, A. L. |4 oth | |
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