Does Perinatal Phenobarbital Exposure Affect Developmental Outcome at Age 2?
The Objective of this paper is to determine if phenobarbital exposure during pregnancy affects developmental outcome at age 2 years. Between 1991 and 1994, 401 pregnant patients at risk for delivery prior to 34 weeks' gestation were invited to participat; 48 mothers declined entry. Before delivery, pharmacy randomized the pregnant women to receive phenobarbital and vitamin K or identically appearing placebo in a blinded fashion. Developmental follow-up at age 2 years was performed. Children from the treatment group scored signifcantly lower on the Bayler Mental Developmental Index (mean MDI ± 1 SD) than children whose mothers were randomized to the placebo group [104 ± 21 ( N = 59) vs. 113 ± 22 ( N = 62), P = 0.023]. Of 36 independent variables, randomization group was one of five that individually contributed to the prediction of the Bayley MDI score ( P < 0.05). It was concluded that perinatal phenobarbital therapy may impair developmental outcome..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
1999 |
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| Erschienen: |
Stuttgart: Georg Thieme Verlag ; 1999 |
| Reproduktion: |
Thieme Zeitschriftenarchive 1980-2007 |
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| Enthalten in: |
Zur Gesamtaufnahme - volume:16 |
| Enthalten in: |
American journal of perinatology - 16(1999), 02 vom: März, Seite 51-60 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Thorp, James A. [VerfasserIn] |
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| Links: |
dx.doi.org [Deutschlandweit zugänglich] |
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| Themen: |
Antenatal exposure |
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| Umfang: |
10 |
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| doi: |
10.1055/s-2007-993836 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLEJ227391578 |
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| 100 | 1 | |a Thorp, James A. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Does Perinatal Phenobarbital Exposure Affect Developmental Outcome at Age 2? |
| 264 | 1 | |a Stuttgart ; New York |b Georg Thieme Verlag |c 1999 | |
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| 520 | |a The Objective of this paper is to determine if phenobarbital exposure during pregnancy affects developmental outcome at age 2 years. Between 1991 and 1994, 401 pregnant patients at risk for delivery prior to 34 weeks' gestation were invited to participat; 48 mothers declined entry. Before delivery, pharmacy randomized the pregnant women to receive phenobarbital and vitamin K or identically appearing placebo in a blinded fashion. Developmental follow-up at age 2 years was performed. Children from the treatment group scored signifcantly lower on the Bayler Mental Developmental Index (mean MDI ± 1 SD) than children whose mothers were randomized to the placebo group [104 ± 21 ( N = 59) vs. 113 ± 22 ( N = 62), P = 0.023]. Of 36 independent variables, randomization group was one of five that individually contributed to the prediction of the Bayley MDI score ( P < 0.05). It was concluded that perinatal phenobarbital therapy may impair developmental outcome. | ||
| 533 | |f Thieme Zeitschriftenarchive 1980-2007 | ||
| 650 | 4 | |a antenatal exposure | |
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| 650 | 4 | |a developmental outcome | |
| 650 | 4 | |a intelligence | |
| 650 | 4 | |a perinatal exposure | |
| 700 | 1 | |a O'Connor, Mary |e verfasserin |4 aut | |
| 700 | 1 | |a Jones, Angela M.H. |e verfasserin |4 aut | |
| 700 | 1 | |a Hoffman, Edward L. |4 oth | |
| 700 | 1 | |a Belden, Brian |4 oth | |
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