Pharmacokinetic and Metabolic Studies of Retrojusticidin B, a Potential Anti-Viral Lignan, in Rats
The pharmacokinetics and metabolism of retrojusticidin B, an anti-HIV reverse transcriptase agent isolated from PHYLLANTHUS MYRITIFOLIUS, were studied in rats. The phase II conjugated metabolites were characterized after solvolysis and enzymatic hydrolysis. The oral bioavailabilities of retrojusticidin B, suspended in Tween 80 and in corn oil, were found to be 22.1 % and 33.1 %, respectively. The elimination half-lives (T 1/2) were 22.9 and 36.2 minutes, respectively. The T 1/2, clearance, and the volume of distribution (Vz) of retrojusticidin B estimated from I. V. measurements were 24.5 min, 2.6 ± 0.4 L/min, and 90.6 ± 6.4 L, respectively. 9,9'-Secoretrojusticidin B was shown to be phase I metabolite. AUC:area under the plasma level-time curve Vz:apparent volume of distribution of the central compartment Cl:clearance C max:maximum peak concentration T max:the time to achieve C max.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2004 |
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| Erschienen: |
Stuttgart: Georg Thieme Verlag ; 2004 |
| Reproduktion: |
Thieme Zeitschriftenarchive 1980-2007 |
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| Enthalten in: |
Zur Gesamtaufnahme - volume:70 |
| Enthalten in: |
Planta medica - 70(2004), 12 vom: Dez., Seite 1161-1165 |
| Sprache: |
Deutsch |
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| Beteiligte Personen: |
Wang, Chen-Yu [VerfasserIn] |
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| Links: |
dx.doi.org [Deutschlandweit zugänglich] |
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| Themen: |
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| Anmerkungen: |
Intermediärsprache: Deutsch |
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| Umfang: |
5 |
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| doi: |
10.1055/s-2004-835845 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLEJ226793680 |
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| 245 | 1 | 0 | |a Pharmacokinetic and Metabolic Studies of Retrojusticidin B, a Potential Anti-Viral Lignan, in Rats |
| 264 | 1 | |a Stuttgart ; New York |b Georg Thieme Verlag |c 2004 | |
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| 500 | |a Intermediärsprache: Deutsch | ||
| 520 | |a The pharmacokinetics and metabolism of retrojusticidin B, an anti-HIV reverse transcriptase agent isolated from PHYLLANTHUS MYRITIFOLIUS, were studied in rats. The phase II conjugated metabolites were characterized after solvolysis and enzymatic hydrolysis. The oral bioavailabilities of retrojusticidin B, suspended in Tween 80 and in corn oil, were found to be 22.1 % and 33.1 %, respectively. The elimination half-lives (T 1/2) were 22.9 and 36.2 minutes, respectively. The T 1/2, clearance, and the volume of distribution (Vz) of retrojusticidin B estimated from I. V. measurements were 24.5 min, 2.6 ± 0.4 L/min, and 90.6 ± 6.4 L, respectively. 9,9'-Secoretrojusticidin B was shown to be phase I metabolite. AUC:area under the plasma level-time curve Vz:apparent volume of distribution of the central compartment Cl:clearance C max:maximum peak concentration T max:the time to achieve C max | ||
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