Photochemische Studien, 64. Photostabilität von Glucocorticoiden in kristallinem Zustand
Photochemical Studies, 64. - Photostability of Glucocorticoids in the Solid StateMost of the pharmacopoeia require that the glucocorticoids hydrocortisone (1), cortisone (2), hydrocortisone 21-acetate (3) and cortisone 21-acetate (4) must be protected from light during storage. The present study shows that UV irradiation of these compounds in the solid state leads to the loss of the side chain at C-17. Two 17-ketosteroids, 11β-hydroxy-4-androstene-3,17-dione (6) and 4-androstene-3,11,17-trione (7), were obtained as photoproducts (yields 3% and 4%, respectively)..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
1992 |
|---|---|
| Erschienen: |
1992 |
| Reproduktion: |
Wiley InterScience Backfile Collection 1832-2000 |
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| Enthalten in: |
Zur Gesamtaufnahme - volume:1992 |
| Enthalten in: |
Liebigs Annalen - 1992(1992) vom: Nov., Seite 1199-1200 |
| Sprache: |
Deutsch |
|---|
| Beteiligte Personen: |
Reisch, Johannes [Sonstige Person] |
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| Links: |
dx.doi.org [Deutschlandweit zugänglich] |
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| Umfang: |
2 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLEJ162404646 |
|---|
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| 520 | |a Photochemical Studies, 64. - Photostability of Glucocorticoids in the Solid StateMost of the pharmacopoeia require that the glucocorticoids hydrocortisone (1), cortisone (2), hydrocortisone 21-acetate (3) and cortisone 21-acetate (4) must be protected from light during storage. The present study shows that UV irradiation of these compounds in the solid state leads to the loss of the side chain at C-17. Two 17-ketosteroids, 11β-hydroxy-4-androstene-3,17-dione (6) and 4-androstene-3,11,17-trione (7), were obtained as photoproducts (yields 3% and 4%, respectively). | ||
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| 700 | 1 | |a Iranshahi, Lotfollah |4 oth | |
| 700 | 1 | |a Ekiz-Gücer, Nurten |4 oth | |
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