Cardioprotective effects of timosaponin B-II isolated from Anemarrhena rhizome in a zebrafish model / Yan-Mei Zhong, Chu-Qin Yu, Meng-Jiao Du, Jian-Ping Chen, Bo-Wen Lian, Wen-Jie Mei, Jia-Xian Yu, Li-Shi Chen, Shan-Bin Deng
Abstract Timosaponin B-II (TB-II; (25S)-26-(β-D-glucopyranosyloxy)-3β-[(2-O-β-D-glucopyranosyl-β-D-galactopyranosyl) oxy]-5β-furostan-22-ol is extracted from Anemarrhena. Its anti-inflammation, anti-oxidation, and anti-asthma properties have been widely explored. However, its effect on the heart has not been reported. In this study, we used zebrafish as a research model to determine the effects of TB-II on the heart and its toxic and anti-inflammatory effects. To explore the cause of cardioprotective effects of TB-II, we used transgenic zebrafish with macrophages and neutrophils labeled with fluorescent protein. We found for the first time that TB-II had a protective effect on the zebrafish heart. It did not affect the survival and hatching rates of zebrafish embryos, indicating its low toxicity. Results showed that TB-II may have cardioprotective effects, which might be related to its anti-inflammatory effects.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:75 |
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| Enthalten in: |
Die Pharmazie |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhong, Yan-Mei [VerfasserIn] |
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| Links: |
FID Access [lizenzpflichtig] |
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| Umfang: |
1 Online-Ressource (4 p) |
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| doi: |
10.1691/ph.2020.9869 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
KFL011218673 |
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| 520 | |a Abstract Timosaponin B-II (TB-II; (25S)-26-(β-D-glucopyranosyloxy)-3β-[(2-O-β-D-glucopyranosyl-β-D-galactopyranosyl) oxy]-5β-furostan-22-ol is extracted from Anemarrhena. Its anti-inflammation, anti-oxidation, and anti-asthma properties have been widely explored. However, its effect on the heart has not been reported. In this study, we used zebrafish as a research model to determine the effects of TB-II on the heart and its toxic and anti-inflammatory effects. To explore the cause of cardioprotective effects of TB-II, we used transgenic zebrafish with macrophages and neutrophils labeled with fluorescent protein. We found for the first time that TB-II had a protective effect on the zebrafish heart. It did not affect the survival and hatching rates of zebrafish embryos, indicating its low toxicity. Results showed that TB-II may have cardioprotective effects, which might be related to its anti-inflammatory effects | ||
| 700 | 1 | |a Yu, Chu-Qin |e verfasserin |4 aut | |
| 700 | 1 | |a Du, Meng-Jiao |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Jian-Ping |e verfasserin |4 aut | |
| 700 | 1 | |a Lian, Bo-Wen |e verfasserin |4 aut | |
| 700 | 1 | |a Mei, Wen-Jie |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Jia-Xian |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Li-Shi |e verfasserin |4 aut | |
| 700 | 1 | |a Deng, Shan-Bin |e verfasserin |4 aut | |
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