Futility stopping in clinical trials, optimality and practical considerations / Yen Chang, Tianhao Song, Jane Monaco, Anastasia Ivanova
ABSTRACT Stopping for futility is a useful tool in a clinical trial. It is widely used in single-arm trials in oncology and in many two-arm trials. We review three stopping rules for futility. We give recommendations for the optimal timing of futility looks in two-stage trials in terms of the information fraction and the probability of stopping under the alternative hypothesis. We discuss futility stopping in trials with substantial uncertainty about the variability of the outcome and in crossover trials.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:30 |
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| Enthalten in: |
Journal of biopharmaceutical statistics - 30(2020), 6, Seite 1050-1059 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Chang, Yen [VerfasserIn] |
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| Links: |
FID Access [lizenzpflichtig] |
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| Themen: |
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| Umfang: |
1 Online-Ressource (10 p) |
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| doi: |
10.1080/10543406.2020.1818253 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a ABSTRACT Stopping for futility is a useful tool in a clinical trial. It is widely used in single-arm trials in oncology and in many two-arm trials. We review three stopping rules for futility. We give recommendations for the optimal timing of futility looks in two-stage trials in terms of the information fraction and the probability of stopping under the alternative hypothesis. We discuss futility stopping in trials with substantial uncertainty about the variability of the outcome and in crossover trials | ||
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