Chemotherapeutic Strategies for Combating Staphylococcus aureus Infections / Namita Sharma, Anil Kumar Chhillar, Sweety Dahiya, Aruna Punia, Pooja Choudhary, Prity Gulia, Akanksha Behl, Mehak Dangi
Abstract: Staphylococcus aureus is a prominent human pathogen that causes nosocomial and communityacquired infections. The accelerating emergence and prevalence of staphylococcal infectionshave grotesque health consequences which are mostly due to its anomalous capability to acquire drugresistance and scarcity of novel classes of antibacterials. Many combating therapies are centered onprimary targets of S. aureus which are cell envelope, ribosomes and nucleic acids. This review describesvarious chemotherapeutic strategies for combating S. aureus infections including monotherapy,combination drug therapy, phage endolysin therapy, lysostaphins and antibacterial drones. Monotherapyhas dwindled in due course of time, but combination therapy, endolysin therapy, lysostaphinand antibacterial drones are emerging alternatives which efficiently conquer the shortcomings ofmonotherapy. Combinations of more than one antibiotic agents or combination of adjuvant with antibioticsprovide a synergistic approach to combat infections causing pathogenic strains. Phage endolysintherapy and lysostaphin are also presented as possible alternatives to conventional antibiotic therapies.Antibacterial Drones go a step further by specifically targeting the virulence genes in bacteria,giving them a certain advantage over existing antibacterial strategies. But the challenge remains on thebetter understanding of these strategies for executing and implementing them in the health sector. Inthis day and age, most of the S. aureus strains are resistant to an ample number of antibiotics, so thereis an urgent need to overcome such multidrug-resistant strains for the welfare of our community.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
|---|---|
| Enthalten in: |
Mini-reviews in ... medicinal chemistry - 22(2022), 1, Seite 17 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Sharma, Namita [VerfasserIn] |
|---|
| Links: |
FID Access [lizenzpflichtig] |
|---|
| Umfang: |
1 Online-Ressource (17 p) |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
KFL011180056 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | KFL011180056 | ||
| 003 | DE-627 | ||
| 005 | 20231128075955.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230613s2022 xx |||||o 00| ||eng c | ||
| 035 | |a (DE-627)KFL011180056 | ||
| 035 | |a (KFL)prod_DARH_.063CC7F34AA02C9729890E13DDC514F9F85E8211 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 084 | |a PHARM |q DE-84 |2 fid | ||
| 100 | 1 | |a Sharma, Namita |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Chemotherapeutic Strategies for Combating Staphylococcus aureus Infections |c Namita Sharma, Anil Kumar Chhillar, Sweety Dahiya, Aruna Punia, Pooja Choudhary, Prity Gulia, Akanksha Behl, Mehak Dangi |
| 264 | 1 | |c 2022 | |
| 300 | |a 1 Online-Ressource (17 p) | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Abstract: Staphylococcus aureus is a prominent human pathogen that causes nosocomial and communityacquired infections. The accelerating emergence and prevalence of staphylococcal infectionshave grotesque health consequences which are mostly due to its anomalous capability to acquire drugresistance and scarcity of novel classes of antibacterials. Many combating therapies are centered onprimary targets of S. aureus which are cell envelope, ribosomes and nucleic acids. This review describesvarious chemotherapeutic strategies for combating S. aureus infections including monotherapy,combination drug therapy, phage endolysin therapy, lysostaphins and antibacterial drones. Monotherapyhas dwindled in due course of time, but combination therapy, endolysin therapy, lysostaphinand antibacterial drones are emerging alternatives which efficiently conquer the shortcomings ofmonotherapy. Combinations of more than one antibiotic agents or combination of adjuvant with antibioticsprovide a synergistic approach to combat infections causing pathogenic strains. Phage endolysintherapy and lysostaphin are also presented as possible alternatives to conventional antibiotic therapies.Antibacterial Drones go a step further by specifically targeting the virulence genes in bacteria,giving them a certain advantage over existing antibacterial strategies. But the challenge remains on thebetter understanding of these strategies for executing and implementing them in the health sector. Inthis day and age, most of the S. aureus strains are resistant to an ample number of antibiotics, so thereis an urgent need to overcome such multidrug-resistant strains for the welfare of our community | ||
| 700 | 1 | |a Chhillar, Anil Kumar |e verfasserin |4 aut | |
| 700 | 1 | |a Dahiya, Sweety |e verfasserin |4 aut | |
| 700 | 1 | |a Punia, Aruna |e verfasserin |4 aut | |
| 700 | 1 | |a Choudhary, Pooja |e verfasserin |4 aut | |
| 700 | 1 | |a Gulia, Prity |e verfasserin |4 aut | |
| 700 | 1 | |a Behl, Akanksha |e verfasserin |4 aut | |
| 700 | 1 | |a Dangi, Mehak |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Mini-reviews in ... medicinal chemistry |d Hilversum, the Netherlands [u.a.] : Bentham Science Publ., 2001 |g 22(2022), 1, Seite 17 |h Online-Ressource |w (DE-627)KFL000006394 |w (DE-600)2104083-7 |w (DE-576)273887203 |x 1875-5607 |7 nnns |
| 773 | 1 | 8 | |g volume:22 |g year:2022 |g number:1 |g pages:17 |
| 856 | 4 | 0 | |u http://pharmazie.proxy.fid-lizenzen.de/fid/bentham-ejournals-pharmazie/www.eurekaselect.com/openurl/content.php?genre=article&issn=1389-5575&volume=22&issue=1&spage=26 |m X:KFL |x Verlag |y FID Access |z lizenzpflichtig |
| 912 | |a ZDB-1-BEJ | ||
| 912 | |a GBV_KFL | ||
| 912 | |a FID-PHARM | ||
| 935 | |i IMPORT_0628_prod_DARH_03 | ||
| 951 | |a AR | ||
| 952 | |d 22 |j 2022 |e 1 |h 17 | ||