Biocatalytic Synthesis of Terpene Esters and their Biological Activity in Human Glioma Cells / Mateusz Kutyła, Aleksandra Maciejczyk, Mariusz Trytek, Joanna Jakubowicz-Gil
Background: Gliomas are highly malignant brain tumours with high resistance to chemotherapy. Therefore, investigations of new therapeutic molecules with high anti-glioma activity are of great importance. Objectives: In this work, biocatalytic esterification of terpene alcohols with proven anti-cancer activity was performed to enhance their potency to induce cell death in human glioblastoma multiforme T98G and anaplastic astrocytoma MOGGCCM cell lines in vitro . Methods and Results: We used primary terpene alcohols and carboxylic acids with a length of two to nine carbon atoms. The structure of the alcohols had an influence on the esterification efficiency, which decreased in the following order: monocyclic > linear > bicyclic. Terpene alcohols and their esters only induced apoptotic cell death, which is highly desirable from a therapeutic point of view, but did not induce autophagy and necrosis. The esterification of perillyl alcohol with butyric acid caused a 4-fold increase in cell death induction in the T98G line. Citronellol valerate, caprylate, and pelargonate and myrtenol butyrate, caprylate and pelargonate also showed higher activity than their alcohol precursors. Conclusion: We have herein shown that esterification of natural alcohols by biocatalysis can be used for improving the activity of other compounds investigated for their anti-glioma activity.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2022 |
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Erschienen: |
2022 |
Enthalten in: |
Zur Gesamtaufnahme - volume:23 |
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Enthalten in: |
Current pharmaceutical biotechnology - 23(2022), 6, Seite 6 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Kutyła, Mateusz [VerfasserIn] |
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Links: |
FID Access [lizenzpflichtig] |
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Umfang: |
1 Online-Ressource (6 p) |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
KFL011171995 |
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