Staphylococcus aureus: Biofilm Formation and Strategies Against it / Ahmad Nasser, Mohammad Mehdi Soltan Dallal, Shiva Jahanbakhshi, Taher Azimi, Leila Nikouei
Abstract: Formation of Staphylococcus aureus biofilm causes significant infections in thehuman body. Biofilm forms through the aggregation of bacterial species and brings about manycomplications. It mediates drug resistance and persistence and facilitates the recurrence ofinfection at the end of antimicrobial therapy. Biofilm formation is completed in a series of steps,and any interference in these steps can disrupt its formation. Such interference may occur at anystage of biofilm production, including attachment, monolayer formation, and accumulation.Interfering agents can act as quorum sensing inhibitors and interfere in the functionality ofquorum sensing receptors, attachment inhibitors, and affect cell hydrophobicity. Among theseinhibiting strategies, attachment inhibitors could serve as the best agents against biofilmformation, because in case pathogens abort the attachment, the next stages of biofilm formation,e.g., accumulation and dispersion, will fail to materialize. Inhibition at this stage leads tosuppression of virulence factors and invasion. One of the best knowing inhibitors is a chelatorthat collects metal, Fe+, Zn+, and magnesium critical for biofilm formation. These effectivefactors in the binding and formation of biofilm are investigated, and the coping strategy isdiscussed. This review examines the stages of biofilm formation and determines what factorsinterfere in the continuity of these steps. Finally, the inhibition strategies are investigated,reviewed, and discussed.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:23 |
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| Enthalten in: |
Current pharmaceutical biotechnology - 23(2022), 5, Seite 15 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Nasser, Ahmad [VerfasserIn] |
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| Links: |
FID Access [lizenzpflichtig] |
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| Umfang: |
1 Online-Ressource (15 p) |
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| Förderinstitution / Projekttitel: |
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| 245 | 1 | 0 | |a Staphylococcus aureus: Biofilm Formation and Strategies Against it |c Ahmad Nasser, Mohammad Mehdi Soltan Dallal, Shiva Jahanbakhshi, Taher Azimi, Leila Nikouei |
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| 520 | |a Abstract: Formation of Staphylococcus aureus biofilm causes significant infections in thehuman body. Biofilm forms through the aggregation of bacterial species and brings about manycomplications. It mediates drug resistance and persistence and facilitates the recurrence ofinfection at the end of antimicrobial therapy. Biofilm formation is completed in a series of steps,and any interference in these steps can disrupt its formation. Such interference may occur at anystage of biofilm production, including attachment, monolayer formation, and accumulation.Interfering agents can act as quorum sensing inhibitors and interfere in the functionality ofquorum sensing receptors, attachment inhibitors, and affect cell hydrophobicity. Among theseinhibiting strategies, attachment inhibitors could serve as the best agents against biofilmformation, because in case pathogens abort the attachment, the next stages of biofilm formation,e.g., accumulation and dispersion, will fail to materialize. Inhibition at this stage leads tosuppression of virulence factors and invasion. One of the best knowing inhibitors is a chelatorthat collects metal, Fe+, Zn+, and magnesium critical for biofilm formation. These effectivefactors in the binding and formation of biofilm are investigated, and the coping strategy isdiscussed. This review examines the stages of biofilm formation and determines what factorsinterfere in the continuity of these steps. Finally, the inhibition strategies are investigated,reviewed, and discussed | ||
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| 700 | 1 | |a Jahanbakhshi, Shiva |e verfasserin |4 aut | |
| 700 | 1 | |a Azimi, Taher |e verfasserin |4 aut | |
| 700 | 1 | |a Nikouei, Leila |e verfasserin |4 aut | |
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