Promising Effects of Naringenin and Melatonin against Hepatic Encephalopathy Impairments Induced by Bile Duct Ligation in Male Rats / Elahe Karami Raviz, Fatemeh Noormand, Ali Sharifzadeh Kermani, Ali Galedari, Khadijeh Esmaeilpour, Marzieh Maneshian, Taj Pari Kalantaripour, Shahriar Dabiri, Majid Asadi-Shekaari
Background: Bile duct ligation (BDL) is used for evaluating the protective effects of different agents with anti-inflammatory and antioxidant properties against the liver and brain damages. Naringenin (N) and melatonin (M) are used as protectants in various models of diseases. Aims: In the current research, the combinational effects of these well-known anti-inflammatory and antioxidants agents were investigated against cerebral injuries induced by BDL in male rats. Methods: The animals were distributed into the following groups: Sham, BDL + Vehicle and BDL+ N + M. Neuronal damages were evaluated using biochemical, motor behavioral tasks and morphological assessments. Results: Based on the data, BDL resulted in decreasing locomotor activity, which was reversed by N and M. Morphological study confirmed that BDL led to neurodegeneration in the cortex of the rats, and the N and M treatment preserved cortical neurons. In addition, immunohistochemical (IHC) study of the rat cortex showed that BDL resulted in increasing the activated astrocytes, and the N and M treatment reduced the number of activated cells. Conclusion: These results obviously depicted combinational therapy with N and M to exert positive effects in the BDL rats, probably due to their synergistic anti-inflammatory and antioxidant activities.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
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| Enthalten in: |
Central nervous system agents in medicinal chemistry - 22(2023), 1, Seite 8 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Raviz, Elahe Karami [VerfasserIn] |
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| Links: |
FID Access [lizenzpflichtig] |
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| Umfang: |
1 Online-Ressource (8 p) |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Background: Bile duct ligation (BDL) is used for evaluating the protective effects of different agents with anti-inflammatory and antioxidant properties against the liver and brain damages. Naringenin (N) and melatonin (M) are used as protectants in various models of diseases. Aims: In the current research, the combinational effects of these well-known anti-inflammatory and antioxidants agents were investigated against cerebral injuries induced by BDL in male rats. Methods: The animals were distributed into the following groups: Sham, BDL + Vehicle and BDL+ N + M. Neuronal damages were evaluated using biochemical, motor behavioral tasks and morphological assessments. Results: Based on the data, BDL resulted in decreasing locomotor activity, which was reversed by N and M. Morphological study confirmed that BDL led to neurodegeneration in the cortex of the rats, and the N and M treatment preserved cortical neurons. In addition, immunohistochemical (IHC) study of the rat cortex showed that BDL resulted in increasing the activated astrocytes, and the N and M treatment reduced the number of activated cells. Conclusion: These results obviously depicted combinational therapy with N and M to exert positive effects in the BDL rats, probably due to their synergistic anti-inflammatory and antioxidant activities | ||
| 700 | 1 | |a Noormand, Fatemeh |e verfasserin |4 aut | |
| 700 | 1 | |a Kermani, Ali Sharifzadeh |e verfasserin |4 aut | |
| 700 | 1 | |a Galedari, Ali |e verfasserin |4 aut | |
| 700 | 1 | |a Esmaeilpour, Khadijeh |e verfasserin |4 aut | |
| 700 | 1 | |a Maneshian, Marzieh |e verfasserin |4 aut | |
| 700 | 1 | |a Kalantaripour, Taj Pari |e verfasserin |4 aut | |
| 700 | 1 | |a Dabiri, Shahriar |e verfasserin |4 aut | |
| 700 | 1 | |a Asadi-Shekaari, Majid |e verfasserin |4 aut | |
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