Nanoencapsulation of Polyphenols as Drugs and Supplements for EnhancingTherapeutic Profile - A Review / Saima Khatoon, Nida Kalam, Mohd. Farooq Shaikh, M Saquib Hasnain, Aurangzeb Khurram Hafiz, Mohammed Tahir Ansari
Polyphenolic phytoconstituents have been widely in use worldwide for ages and are categorisedas secondary metabolites of plants. The application of polyphenols such as quercetin,resveratrol, curcumin as nutritional supplements has been researched widely. The use of polyphenolsand specifically quercetin, for improving memory and mental endurance has shown significanteffects among rats. Even though similar results have not been resonated among humans, butpreclinical results have encouraged researchers to explore other polyphenols to study the effects assupplements among athletes. The phytopharmacological research has elucidated the use of naturalpolyphenols to prevent and treat various physiological and metabolic disorders owing to their freeradical scavenging properties, anti-inflammatory, anti-cancer, and immunomodulatory effects. In--spite of the tremendous pharmacological profile, one of the most dominant problem regarding theuse of polyphenolic compounds is their low bioavailability. Nanonization is considered as one ofthe most prominent approaches among many. This article aims to review and discuss the molecularmechanisms of recently developed nanocarrier-based drug delivery systems for polyphenols andtheir application as drugs and supplements. Nanoformulations of natural polyphenols as bioactiveagents, such as quercetin, kaempferol, fisetin, rutin, hesperetin, and naringenin epigalloccatechin-3-gallate, genistein, ellagic acid, gallic acid, chlorogenic acid, ferulic acid, curcuminoids, andstilbenes is expected to have better efficacy. These delivery systems are expected to provide higherpenetrability of polyphenols at cellular levels and exhibit a controlled release of the drugs. It iswidely accepted that natural polyphenols do demonstrate significant therapeutic effects. However,the hindrances in their absorption, specificity, and bioavailability can be overcome using nanotechnology.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
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| Enthalten in: |
Current molecular pharmacology - 15(2022), 1, Seite 31 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Khatoon, Saima [VerfasserIn] |
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| Links: |
FID Access [lizenzpflichtig] |
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| Umfang: |
1 Online-Ressource (31 p) |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Polyphenolic phytoconstituents have been widely in use worldwide for ages and are categorisedas secondary metabolites of plants. The application of polyphenols such as quercetin,resveratrol, curcumin as nutritional supplements has been researched widely. The use of polyphenolsand specifically quercetin, for improving memory and mental endurance has shown significanteffects among rats. Even though similar results have not been resonated among humans, butpreclinical results have encouraged researchers to explore other polyphenols to study the effects assupplements among athletes. The phytopharmacological research has elucidated the use of naturalpolyphenols to prevent and treat various physiological and metabolic disorders owing to their freeradical scavenging properties, anti-inflammatory, anti-cancer, and immunomodulatory effects. In--spite of the tremendous pharmacological profile, one of the most dominant problem regarding theuse of polyphenolic compounds is their low bioavailability. Nanonization is considered as one ofthe most prominent approaches among many. This article aims to review and discuss the molecularmechanisms of recently developed nanocarrier-based drug delivery systems for polyphenols andtheir application as drugs and supplements. Nanoformulations of natural polyphenols as bioactiveagents, such as quercetin, kaempferol, fisetin, rutin, hesperetin, and naringenin epigalloccatechin-3-gallate, genistein, ellagic acid, gallic acid, chlorogenic acid, ferulic acid, curcuminoids, andstilbenes is expected to have better efficacy. These delivery systems are expected to provide higherpenetrability of polyphenols at cellular levels and exhibit a controlled release of the drugs. It iswidely accepted that natural polyphenols do demonstrate significant therapeutic effects. However,the hindrances in their absorption, specificity, and bioavailability can be overcome using nanotechnology | ||
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