Chemistry, Pharmacokinetics, Pharmacodynamics and Analytical Methodsof Bilastine, a Histamine H1 Receptor Antagonist: An Update / Sanjay Sharma, Ketan Hatware, Prashant Bhadane, Kiran Patil
Abstract: Bilastine (BIL) is the new generation antihistamine that is used to relieve the symptoms ofhayfever, chronic urticaria and other forms of allergic rhinitis. Chemically it is known 2-[4-[2-[4-[1-(2-ethoxyethyl) benzimidazole-2-yl] piperidine-1-yl] ethyl] phenyl]-2-methylpropane acid. The chemicalstructure of BIL having a hydrophilic carboxylic substituent. BIL has a longer duration of actiondue to its potent binding affinity to the H1 receptor. This review summarizes the properties, characteristics,chemistry along with analytical and bioanalytical methods used for estimation of BIL from differentscientific articles. The literature has demonstrated some methods for quantification of BIL invarious sample matrix and pharmaceutical products. Frequently and extensively used antihistaminicsare in the clinic practice, a novel, effective, economic and safe analytical methodology is required forroutine quality control analysis, bioavailability, and bioequivalence studies. Furthermore, this narrativereview summarizes available data on chemistry, pharmacology and analysis of BIL in a differentmatrix.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:21 |
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| Enthalten in: |
Mini-reviews in ... medicinal chemistry - 21(2021), 20, Seite 8 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sharma, Sanjay [VerfasserIn] |
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| Links: |
FID Access [lizenzpflichtig] |
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| Umfang: |
1 Online-Ressource (8 p) |
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| Förderinstitution / Projekttitel: |
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| 245 | 1 | 0 | |a Chemistry, Pharmacokinetics, Pharmacodynamics and Analytical Methodsof Bilastine, a Histamine H1 Receptor Antagonist: An Update |c Sanjay Sharma, Ketan Hatware, Prashant Bhadane, Kiran Patil |
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| 520 | |a Abstract: Bilastine (BIL) is the new generation antihistamine that is used to relieve the symptoms ofhayfever, chronic urticaria and other forms of allergic rhinitis. Chemically it is known 2-[4-[2-[4-[1-(2-ethoxyethyl) benzimidazole-2-yl] piperidine-1-yl] ethyl] phenyl]-2-methylpropane acid. The chemicalstructure of BIL having a hydrophilic carboxylic substituent. BIL has a longer duration of actiondue to its potent binding affinity to the H1 receptor. This review summarizes the properties, characteristics,chemistry along with analytical and bioanalytical methods used for estimation of BIL from differentscientific articles. The literature has demonstrated some methods for quantification of BIL invarious sample matrix and pharmaceutical products. Frequently and extensively used antihistaminicsare in the clinic practice, a novel, effective, economic and safe analytical methodology is required forroutine quality control analysis, bioavailability, and bioequivalence studies. Furthermore, this narrativereview summarizes available data on chemistry, pharmacology and analysis of BIL in a differentmatrix | ||
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