Ethanol Extract of Achillea fragrantissima Enhances Angiogenesis through Stimulation of VEGF Production / Hana M. Hammad, Amer Imraish, Maysa Al-Hussaini, Malek Zihlif, Amani A. Harb, Tuqa M. Abu Thiab, Zainab Lafi, Zeyad D. Nassar, Fatma U. Afifi
Objective: Achillea fragrantissima L. (Asteraceae) is a traditionally used medicinal herbin the rural communities of Jordan. Methods: The present study evaluated the efficacy of the ethanol extract of this species on angiogenesisin both, ex vivo using a rat aortic ring assay and in vivo using a rat excision wound model. Results: In concentrations of 50 and 100 μg/ml, the ethanol extract showed angiogenic stimulatoryeffect and significantly increased length of capillary protrusions around aorta rings of about 60% incomparison to those of untreated aorta rings. In MCF-7 cells, the ethanol extract of A. fragrantissimastimulated the production of VEGF in a dose-dependent manner. 1% and 5% of ethanol extractof A. fragrantissima containing vaseline based ointment was applied on rat excision woundsfor six days and found to be effective in wound healing and maturation of the scar. Both preparationsresulted in better wound healing when compared to the untreated control group and vaseline-treated group. This effect was comparable to that induced by MEBO, the positive control. Conclusion: The results indicate that A. fragrantissima has a pro-angiogenic effect, which may actthrough the VEGF signaling pathway.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:21 |
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| Enthalten in: |
Endocrine, metabolic & immune disorders, drug targets - 21(2021), 11, Seite 8 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hammad, Hana M. [VerfasserIn] |
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| Links: |
FID Access [lizenzpflichtig] |
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| Umfang: |
1 Online-Ressource (8 p) |
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| Förderinstitution / Projekttitel: |
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| 245 | 1 | 0 | |a Ethanol Extract of Achillea fragrantissima Enhances Angiogenesis through Stimulation of VEGF Production |c Hana M. Hammad, Amer Imraish, Maysa Al-Hussaini, Malek Zihlif, Amani A. Harb, Tuqa M. Abu Thiab, Zainab Lafi, Zeyad D. Nassar, Fatma U. Afifi |
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| 520 | |a Objective: Achillea fragrantissima L. (Asteraceae) is a traditionally used medicinal herbin the rural communities of Jordan. Methods: The present study evaluated the efficacy of the ethanol extract of this species on angiogenesisin both, ex vivo using a rat aortic ring assay and in vivo using a rat excision wound model. Results: In concentrations of 50 and 100 μg/ml, the ethanol extract showed angiogenic stimulatoryeffect and significantly increased length of capillary protrusions around aorta rings of about 60% incomparison to those of untreated aorta rings. In MCF-7 cells, the ethanol extract of A. fragrantissimastimulated the production of VEGF in a dose-dependent manner. 1% and 5% of ethanol extractof A. fragrantissima containing vaseline based ointment was applied on rat excision woundsfor six days and found to be effective in wound healing and maturation of the scar. Both preparationsresulted in better wound healing when compared to the untreated control group and vaseline-treated group. This effect was comparable to that induced by MEBO, the positive control. Conclusion: The results indicate that A. fragrantissima has a pro-angiogenic effect, which may actthrough the VEGF signaling pathway | ||
| 700 | 1 | |a Imraish, Amer |e verfasserin |4 aut | |
| 700 | 1 | |a Al-Hussaini, Maysa |e verfasserin |4 aut | |
| 700 | 1 | |a Zihlif, Malek |e verfasserin |4 aut | |
| 700 | 1 | |a Harb, Amani A. |e verfasserin |4 aut | |
| 700 | 1 | |a Abu Thiab, Tuqa M. |e verfasserin |4 aut | |
| 700 | 1 | |a Lafi, Zainab |e verfasserin |4 aut | |
| 700 | 1 | |a Nassar, Zeyad D. |e verfasserin |4 aut | |
| 700 | 1 | |a Afifi, Fatma U. |e verfasserin |4 aut | |
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