Antihyperglycemic Activity of Aqueous Extract of Euphorbia guyoniana inStreptozotocin-Induced Diabetic Rats / Ayoub Amssayef, Bouchra Azzaoui, Ismail Bouadid, Mohamed Eddouks
Aims: This work assessed the antihyperglycemic effect of Euphorbia guyoniana. Background: Euphorbia guyoniana (Boss. and Reut.) is widely used in traditional medicine. Objective: This study was designed to confirm this traditional use by assessing its antihyperglycemiccapacity in vivo. Methods: The effect of the aqueous extract of Euphorbia guyoniana (Boss. and Reut.) (60 mg/kg)on glycemia in both normal and diabetic rats was evaluated. The glycogen content in the liver andskeletal muscles (extensor digitorum longus and soleus) was measured. Furthermore, liver histopathologicalanalysis was performed. Results: The findings showed that Euphorbia guyoniana (Boss. and Reut.) exhibited a significantdecrease in glycaemia in diabetic rats (from 20±2 mmol/l to 5.5 mmol/l after 6 hours of oral administration;p<0.0001 and from 20±2 mmol/l to 4.5 mmol/l after 7 days of once-daily repeated oral administrationof the aqueous Euphorbia guyoniana extract; p<0.0001). In addition, the extract increasedthe glycogen content in the liver (41±4 mg/g versus 70±5 mg/g in normal and diabetic ratsrespectively) and extensor digitorum longus (39±4 mg/g versus 60±1 mg/g in normal and diabeticrats, respectively), and partially restored corporal weight in diabetic rats. Furthermore, this aqueousextract has been shown to suppress hyperglycemia induced by glucose load in treated diabetic rats.Additionally, hepatic histology in diabetic rats has been improved. This plant revealed the presenceof several phytochemical constituents and possessed antioxidant activity. Conclusion: The current study evidenced that Euphorbia guyoniana (Boss. and Reut.) has a beneficialeffect on improving hyperglycemia and glycogen depletion in the diabetic state.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:21 |
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| Enthalten in: |
Cardiovascular & hematological disorders, drug targets - 21(2021), 4, Seite 10 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Amssayef, Ayoub [VerfasserIn] |
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| Links: |
FID Access [lizenzpflichtig] |
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| Umfang: |
1 Online-Ressource (10 p) |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
KFL011148322 |
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| 245 | 1 | 0 | |a Antihyperglycemic Activity of Aqueous Extract of Euphorbia guyoniana inStreptozotocin-Induced Diabetic Rats |c Ayoub Amssayef, Bouchra Azzaoui, Ismail Bouadid, Mohamed Eddouks |
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| 520 | |a Aims: This work assessed the antihyperglycemic effect of Euphorbia guyoniana. Background: Euphorbia guyoniana (Boss. and Reut.) is widely used in traditional medicine. Objective: This study was designed to confirm this traditional use by assessing its antihyperglycemiccapacity in vivo. Methods: The effect of the aqueous extract of Euphorbia guyoniana (Boss. and Reut.) (60 mg/kg)on glycemia in both normal and diabetic rats was evaluated. The glycogen content in the liver andskeletal muscles (extensor digitorum longus and soleus) was measured. Furthermore, liver histopathologicalanalysis was performed. Results: The findings showed that Euphorbia guyoniana (Boss. and Reut.) exhibited a significantdecrease in glycaemia in diabetic rats (from 20±2 mmol/l to 5.5 mmol/l after 6 hours of oral administration;p<0.0001 and from 20±2 mmol/l to 4.5 mmol/l after 7 days of once-daily repeated oral administrationof the aqueous Euphorbia guyoniana extract; p<0.0001). In addition, the extract increasedthe glycogen content in the liver (41±4 mg/g versus 70±5 mg/g in normal and diabetic ratsrespectively) and extensor digitorum longus (39±4 mg/g versus 60±1 mg/g in normal and diabeticrats, respectively), and partially restored corporal weight in diabetic rats. Furthermore, this aqueousextract has been shown to suppress hyperglycemia induced by glucose load in treated diabetic rats.Additionally, hepatic histology in diabetic rats has been improved. This plant revealed the presenceof several phytochemical constituents and possessed antioxidant activity. Conclusion: The current study evidenced that Euphorbia guyoniana (Boss. and Reut.) has a beneficialeffect on improving hyperglycemia and glycogen depletion in the diabetic state | ||
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| 700 | 1 | |a Bouadid, Ismail |e verfasserin |4 aut | |
| 700 | 1 | |a Eddouks, Mohamed |e verfasserin |4 aut | |
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