Anti-Inflammatory, Anti-Oxidant, and Anti-Lipaemic Effects of Daily DietaryCoenzyme-Q10 Supplement in a Mouse Model of Metabolic Syndrome / Olakunle J. Onaolapo, Sarafa A. Omotoso, Anthony T. Olofinnade, Adejoke Y. Onaolapo
Background: The dietary model of metabolic syndrome has continued to aid our understandingof its pathogenesis and possible management interventions. However, despite progress inresearch, therapy continues to be challenging for humans; hence, the search for newer treatmentand prevention options continues. Objective: The objective of this study was to evaluate the impact of dietary CQ10 supplementationon metabolic, oxidative, and inflammatory markers in a diet-induced mouse model of metabolicsyndrome. Methods: Mouse groups were fed a Standard Diet (SD), High-Fat High-Sugar (HFHS) diet, andSD or HFHS diet (with incorporated CQ10) at 60 and 120 mg/kg of feed. At the completion of thestudy (8 weeks), blood glucose levels, Superoxide Dismutase (SOD) activity, plasma insulin,leptin, adiponectin, TNF-α, IL-10, serum lipid profile, and Lipid Peroxidation (LPO) levels were assessed.The liver was either homogenised for the assessment of antioxidant status or processed forgeneral histology. Results: Dietary CQ10 mitigated HFHS diet-induced weight gain, decreased glucose, insulin, andleptin levels, and increased adiponectin levels in mice. Coenzyme-Q10 improved the antioxidant statusof the liver and blood in HFHS diet-fed mice while also decreasing lipid peroxidation. Lipidprofile improved, level of TNF-α decreased, and IL-10 increased following CQ10 diet. A mitigationof HFHS diet-induced alteration in liver morphology was also observed with CQ10. Conclusion: Dietary CQ10 supplementation mitigates HFHS diet-induced changes in mice, possiblythrough its anti-oxidant, anti-lipaemic, and anti-inflammatory potential.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:20 |
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| Enthalten in: |
Anti-inflammatory & anti-allergy agents in medicinal chemistry - 20(2021), 4, Seite 9 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Onaolapo, Olakunle J. [VerfasserIn] |
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| Links: |
FID Access [lizenzpflichtig] |
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| Umfang: |
1 Online-Ressource (9 p) |
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| Förderinstitution / Projekttitel: |
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| 245 | 1 | 0 | |a Anti-Inflammatory, Anti-Oxidant, and Anti-Lipaemic Effects of Daily DietaryCoenzyme-Q10 Supplement in a Mouse Model of Metabolic Syndrome |c Olakunle J. Onaolapo, Sarafa A. Omotoso, Anthony T. Olofinnade, Adejoke Y. Onaolapo |
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| 520 | |a Background: The dietary model of metabolic syndrome has continued to aid our understandingof its pathogenesis and possible management interventions. However, despite progress inresearch, therapy continues to be challenging for humans; hence, the search for newer treatmentand prevention options continues. Objective: The objective of this study was to evaluate the impact of dietary CQ10 supplementationon metabolic, oxidative, and inflammatory markers in a diet-induced mouse model of metabolicsyndrome. Methods: Mouse groups were fed a Standard Diet (SD), High-Fat High-Sugar (HFHS) diet, andSD or HFHS diet (with incorporated CQ10) at 60 and 120 mg/kg of feed. At the completion of thestudy (8 weeks), blood glucose levels, Superoxide Dismutase (SOD) activity, plasma insulin,leptin, adiponectin, TNF-α, IL-10, serum lipid profile, and Lipid Peroxidation (LPO) levels were assessed.The liver was either homogenised for the assessment of antioxidant status or processed forgeneral histology. Results: Dietary CQ10 mitigated HFHS diet-induced weight gain, decreased glucose, insulin, andleptin levels, and increased adiponectin levels in mice. Coenzyme-Q10 improved the antioxidant statusof the liver and blood in HFHS diet-fed mice while also decreasing lipid peroxidation. Lipidprofile improved, level of TNF-α decreased, and IL-10 increased following CQ10 diet. A mitigationof HFHS diet-induced alteration in liver morphology was also observed with CQ10. Conclusion: Dietary CQ10 supplementation mitigates HFHS diet-induced changes in mice, possiblythrough its anti-oxidant, anti-lipaemic, and anti-inflammatory potential | ||
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