Anti-inflammatory Effect ofWoodfordia fructicosaLeaves Ethanolic Extract on Adjuvant and Carragenan Treated Rats / Hem Raj, Avneet Gupta, Neeraj Upmanyu

Background: Woodfordia fructicosa is used traditionally for the treatment of inflammation associated with arthritis. Methods: In the present study, the anti-inflammatory activity of W. fructicosa (WFE) leaves ethanolic extract was assessed in Sprague Dawley rats by giving 200 mg/kg dose orally. Inflammation was studied by using carrageenan induced paw edema, Freund’s adjuvant (FA) and monosodium iodo acetate (MIA) induced arthritis as animal models. Serum tumor necrosis factor-alpha (TNF-α) was estimated in blood sample of animals treated with FA. The one way ANOVA followed by Bonferroni’s test was used for statistical analysis. Results: WFE significantly decreased (P<0.05, P<0.001) paw thickness in carrageenan induced paw edema and FA induced arthritis. The significant decrease in knee diameter (P<0.001) in MIA induced arthritis as well as inhibitory effect (P<0.001) on elevated TNF- α was observed. Conclusion: These results showed that the WFEexerted an inhibitory effect on TNF-α and carrageenan paw edema which may justify its traditional use in inflammatory conditions. Thus, the study shows that leaves of W. fruticose afford anti-inflammatory activity by preventing the inflammation in different animal models.

Medienart:	E-Artikel

Erscheinungsjahr:	2020
Erschienen:	2020

Enthalten in:	Zur Gesamtaufnahme - volume:19
Enthalten in:	Anti-inflammatory & anti-allergy agents in medicinal chemistry - 19(2020), 2, Seite 10

Sprache:	Englisch

Beteiligte Personen:	Raj, Hem [VerfasserIn] Gupta, Avneet [VerfasserIn] Upmanyu, Neeraj [VerfasserIn]

Links:	FID Access [lizenzpflichtig]

Umfang:	1 Online-Ressource (10 p)

Förderinstitution / Projekttitel:

PPN (Katalog-ID):	KFL011142650