Cytotoxic activity and antioxidant effects ofOriganum onitesessential oil and its two major contents, carvacrol andp-cymene on human colorectal (HCT116) and hepatocelluler carcinoma (HepG2) cell lines / Eda Becer, Ergül Mutlu Altundag, K. Hüsnü Can Başer, Hafize Seda Vatansever
ABSTRACT Origanum onites L. ( O. onites ) is one of the cultivated Origanum species in Turkey. The aim of this study was to determine the cytotoxicity and cellular antioxidant effects of O. onites essential oil, carvacrol and p- cymene on HCT116 and HepG2 cells. O. onites essential oil components were analyzed by GC/MS and GC/FID. Cytotoxicity was analyzed via the MTT assay in HCT116 and HepG2 cells. Cellular antioxidant activities of O. onites essential oil, carvacrol and p -cymene were determined with DCFH-DA method. GC/MS analysis identified carvacrol (%78.4) as the main constituent of O. onites essential oil. 400 µg/ml concentration of O. onites essential oil, carvacrol and p -cymene were found to be active against HCT116 and HepG2 cells. Also, carvacrol showed higher cellular antioxidant activity than O. onites essential oil and p- cymene. We conclude that O. onites essential oil and carvacrol may be a candidate for pharmaceutical products in treatment of cancer.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:34 |
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| Enthalten in: |
The Journal of essential oil research - 34(2022), 6, Seite 514-523 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Becer, Eda [VerfasserIn] |
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| Links: |
FID Access [lizenzpflichtig] |
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| Themen: |
Antioxidant |
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| Umfang: |
1 Online-Ressource (10 p) |
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| doi: |
10.1080/10412905.2022.2107101 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 245 | 1 | 0 | |a Cytotoxic activity and antioxidant effects ofOriganum onitesessential oil and its two major contents, carvacrol andp-cymene on human colorectal (HCT116) and hepatocelluler carcinoma (HepG2) cell lines |c Eda Becer, Ergül Mutlu Altundag, K. Hüsnü Can Başer, Hafize Seda Vatansever |
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| 520 | |a ABSTRACT Origanum onites L. ( O. onites ) is one of the cultivated Origanum species in Turkey. The aim of this study was to determine the cytotoxicity and cellular antioxidant effects of O. onites essential oil, carvacrol and p- cymene on HCT116 and HepG2 cells. O. onites essential oil components were analyzed by GC/MS and GC/FID. Cytotoxicity was analyzed via the MTT assay in HCT116 and HepG2 cells. Cellular antioxidant activities of O. onites essential oil, carvacrol and p -cymene were determined with DCFH-DA method. GC/MS analysis identified carvacrol (%78.4) as the main constituent of O. onites essential oil. 400 µg/ml concentration of O. onites essential oil, carvacrol and p -cymene were found to be active against HCT116 and HepG2 cells. Also, carvacrol showed higher cellular antioxidant activity than O. onites essential oil and p- cymene. We conclude that O. onites essential oil and carvacrol may be a candidate for pharmaceutical products in treatment of cancer | ||
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