N-Acetyltransferase 2, glutathione S-transferase gene polymorphisms and susceptibility to hepatocellular carcinoma in an Algerian population / Lamia Chorfi, Azzedine Fercha, Faouzia Derouiche, Fatima Zohra Sebihi, Dallal Houhou, Keltoum Chorfi, Katia Bendjemana
Abstract This study was conducted to investigate the potential association of genetic polymorphisms of glutathione S-transferase M1/T1 ( GSTM1 , GSTT1 ), and N-acetyltransferase 2 ( NAT2 ) genes and epidemiological parameters with the risk of HCC in the Algerian population. A case-control study including 132 confirmed HCC patients and 141 cancer-free controls was performed. Genotyping analysis was performed using conventional multiplex PCR and PCR-RFLP. Statistical analysis was performed using the Chi-square test. Logistic regression analysis was used to estimate odds ratios and 95% confidence intervals (95% CI). GSTM1 null and NAT2 slow acetylator genotypes confer an increased risk to HCC (OR = 1.88, 95% CI 1.16–3.05; OR = 2.30, 95% CI 1.26–4.18, respectively). This association was prevalent in smokers (OR = 2.00, 95% CI 1.05–3.8 and OR = 2.55, 95% CI 1.22–5.34, respectively). No significant association was observed for GSTT1 null genotype in the contribution to HCC risk (OR = 0.76, 95% CI 0.46–1.27). In conclusion, the GSTM1 and NAT2 gene polymorphisms are positively associated with the risk of HCC in older men and especially in smokers.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:52 |
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| Enthalten in: |
Xenobiotica - 52(2022), 1, Seite 99-104 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Chorfi, Lamia [VerfasserIn] |
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| Links: |
FID Access [lizenzpflichtig] |
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| Themen: |
GSTM1 |
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| Umfang: |
1 Online-Ressource (6 p) |
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| doi: |
10.1080/00498254.2022.2040642 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Abstract This study was conducted to investigate the potential association of genetic polymorphisms of glutathione S-transferase M1/T1 ( GSTM1 , GSTT1 ), and N-acetyltransferase 2 ( NAT2 ) genes and epidemiological parameters with the risk of HCC in the Algerian population. A case-control study including 132 confirmed HCC patients and 141 cancer-free controls was performed. Genotyping analysis was performed using conventional multiplex PCR and PCR-RFLP. Statistical analysis was performed using the Chi-square test. Logistic regression analysis was used to estimate odds ratios and 95% confidence intervals (95% CI). GSTM1 null and NAT2 slow acetylator genotypes confer an increased risk to HCC (OR = 1.88, 95% CI 1.16–3.05; OR = 2.30, 95% CI 1.26–4.18, respectively). This association was prevalent in smokers (OR = 2.00, 95% CI 1.05–3.8 and OR = 2.55, 95% CI 1.22–5.34, respectively). No significant association was observed for GSTT1 null genotype in the contribution to HCC risk (OR = 0.76, 95% CI 0.46–1.27). In conclusion, the GSTM1 and NAT2 gene polymorphisms are positively associated with the risk of HCC in older men and especially in smokers | ||
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